Step I Oxygen Dissociation Curve in Sickle Cell Anemia

[Paramyxovirus]

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Ahem, can someone kindly explain why there is right sided shift of oxygen dissociation curve in SCD?

Thanks in advance!

 

[Northerncardinal]

cuz of inc 2, 3 BPG due to chronic anemia.

there is compensatory inc glycolysis in RBCs cuz of hypoxia

 

[Paramyxovirus]

cuz of inc 2, 3 BPG due to chronic anemia.

there is compensatory inc glycolysis in RBCs cuz of hypoxia

Thanks! Does this right sided shift happen in all kinds of Anemias?

 

[Northerncardinal]

yes. in chronic anemias. I remember Goljan mentions the curve doesn't shift in anemia (hez referring to acute changes i think) and uworld mentions the inc in 2,3 BPG in RBCs in chronic anemias that'd eventually shift the curve to the right.

 

[Paramyxovirus]

Thank you very much for the clarification! 🙂