Read yet another article today highlighting the beneficial effects of early goal directed therapy in sepsis. Wondering what the thoughts of others are on treating sepsis early in the prehospital setting. I'm thinking that if you had at least 20 min transport this might show some benefit for the sicker patients. Identification by history, vitals, and point of care lactate could narrow down patients that would actually benefit. Maybe a protocol combining oxygen therapy, rapid and aggressive fluid boluses, and possibly broad spectrum IV antibiotics (vancomycin+ceftriaxone?).