Part One Biochemistry

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foxydentist

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Hey guys I thought of arranging the forum a bit by making a thread for each section for NBDE part one.... so if any body got any questions or need help in or got new useful infromation wana share in Biochemistry writes here......... 🙂 hope that would make it easy for everybody planning to take part one soon .. (like me 😳 )
 
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foxydentist said:
Hey guys I thought of arranging the forum a bit by making a thread for each section for NBDE part one.... so if any body got any questions or need help in or got new useful infromation wana share in Biochemistry writes here......... 🙂 hope that would make it easy for everybody planning to take part one soon .. (like me 😳 )
Click to expand...

According to those who have taken part one recently Biochem has been the most challenging part of the test. so it's the best way to help each other by posting in this Thread.
Good luck
 
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foxydentist , this is really a good idea having an independent thread for every individual section of this exam,, I just have a question, , is it true that "Kaplan" review book isn't enough for Biochemistry<? thanks 🙂
 
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well ure welcome....
About Kaplan review book.,,,, i have no idea,,, i am studying from it too... check out the dental decks...tc.. good luck
 
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industrious1 said:
foxydentist , this is really a good idea having an independent thread for every individual section of this exam,, I just have a question, , is it true that "Kaplan" review book isn't enough for Biochemistry<? thanks 🙂
Click to expand...

As far as I know everyone refering to "Lippincot" by: Pamela as Ref. for Biochemistry.
 
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dentethic said:
As far as I know everyone refering to "Lippincot" by: Pamela as Ref. for Biochemistry.
Click to expand...

SO what is the right approach to prepare for biochemistry.
i am doing review book adn decks.
what topics should i look for in lippincot.
thanks
 
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hi i am a new member and i wanna know the enough time to study NDB1 coz i only have 3 months ,and about exams if anyone have and can email me
thanks alot🙂
 
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🙂 hi i am a new member and i wanna know the enough time to study NDB1 coz i only have 3 months ,and about exams if anyone have and can email me
thanks alot🙂
 
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Splicing is done by snRNA(small nuclear RNA)
but i have no idea which RNA is responsible for capping. But capping only occur in mRNA. Pls correct me if I am wrong.
 
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mrswinidm said:
Splicing is done by snRNA(small nuclear RNA)
but i have no idea which RNA is responsible for capping. But capping only occur in mRNA. Pls correct me if I am wrong.
Click to expand...

Thanks mrswinidim for the answers

What about this one:
- Basic principles for DNA sequencing by sanger procedure is derived from:
a)translation
b)transcription
c)replication
d)reverse transcription

a or c ? and your Explanation please.
 
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You are welcome. For me the answer is c
because the template is DNA to replicate DNA.
mRNA to protein = translation
DNA to RNA = transcription
DNA to DNA = replication
RNA to cDNA = reverse transcription
Hope this answer your question.
 
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Sorry. One more point.
Sanger procedure use to replicate single stranded DNA using DNA polymerase. enzyme.
DNA to RNA - RNA polymerase
RNA to DNA - Reverse Transcriptase
 
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industrious1 said:
foxydentist , this is really a good idea having an independent thread for every individual section of this exam,, I just have a question, , is it true that "Kaplan" review book isn't enough for Biochemistry<? thanks 🙂
Click to expand...


Part one is really hard compared to part 2😱 . But if you have sufficient source and a good study plan--it really helps. Biochem is the most challenging one--the only book that really saved me was DIGGING UP THE BONES-BIOCHEMISTRY. Its a reviewer for medical student. All important topics are well explained in a very simple manner( small in size). Thats the only book that made me like biochem:laugh: you can buy it at amazon.com --its very cheap and it will really help you A LOT! 😛
goodluck and study hard👍
 
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foxydentist that's a good idea and we like you to open a new thread for other subjects

industrious1 said:
foxydentist , this is really a good idea having an independent thread for every individual section of this exam,, I just have a question, , is it true that "Kaplan" review book isn't enough for Biochemistry<? thanks 🙂
Click to expand...

i think u will waste your time in kaplan part for biochemistry !:laugh:

:idea:

you should look for lippincot it is very good review book 👍
 
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dentethic; 114-Methyl xanthines such as caffeine and theophylline enhance lipolysis in adipose tissue by: A- induced adenylate cyclase synthesis. B- induced triglyceride lipase synthesis. [COLOR="Red" said:
[/COLOR]C- inhibiting cyclic AMP phosphodiestrase activity.
D- directlyactivating an interacellularprotein kinase.
E- enhancing the binding of epinephrine to an extracellular membrane receptor.

115-Which of the following can increase the rate of net flux or diffusion of oxygen through the alveolar membrane?
A- Decreasing temprature
B- Increasing the cross-sectional area
C- Decreasing the concentration gradient
D- Increasing the path length of diffusion

118-Which of the following represents the principle allosteric regulator of pyruvate methabolism in the liver?
A- ATP
B- NAD
C-citrate
D-cyclic AMP
[B]E-Acetyl CoA

128-Which of the following statements BEST describes the activity of DNA ligase?
A- seals single-stranded nicks in DNA.
B- proofreads the DNA proper base paring.
C- prevents the polymerase from falling off the DNA.
D- Removes the RNA primer from the lagging strand.

147-Which of the following represents the sensory organs concerned with maintenance of skeletal muscle tonus?
A- sarcomeres
B- Muscle spindles
C- Gamma efferents
D- Pacinian corpuscles
E- Golgi tendon organs

159-Which of the following functional group are essential for a substance to act as a amphipathic (amphiphilic) molecule?
A- Polar, nonpolar
B- Polar, negatively charged
C- Nonpolar, positively charged
D- Cyclic, hydrophilic
E- Branched, Hydrophilic

162-which of the following natural metabolism measured clinically as a predictor of glomerular filtration rate?
A- Renin
B- Inulin
C- Fructose
D- Creatinine
E- Angiotensin

183-Which of the following represents the compound that contains an active (labile) methyl group?
A- Serine
B- Creatine
C- Methionine
D- S-adenosyl methionine


184-Production of phosphoenolpyruvate carboxykinase is stimulated by
A- onsulin
B- cortisol
C- aldostrone
D- somatotropin.

Thanks everyone for the contribution.
Click to expand...
 
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115-Which of the following can increase the rate of net flux or diffusion of oxygen through the alveolar membrane?
A- Decreasing temprature
B- Increasing the cross-sectional area
C- Decreasing the concentration gradient
D- Increasing the path length of diffusion

128-Which of the following statements BEST describes the activity of DNA ligase?
A- seals single-stranded nicks in DNA.
B- proofreads the DNA proper base paring.
C- prevents the polymerase from falling off the DNA.
D- Removes the RNA primer from the lagging strand.

147-Which of the following represents the sensory organs concerned with maintenance of skeletal muscle tonus?
A- sarcomeres
B- Muscle spindles
C- Gamma efferents
D- Pacinian corpuscles
E- Golgi tendon organs

159-Which of the following functional group are essential for a substance to act as a amphipathic (amphiphilic) molecule?
A- Polar, nonpolar
B- Polar, negatively charged
C- Nonpolar, positively charged
D- Cyclic, hydrophilic
E- Branched, Hydrophilic

162-which of the following natural metabolism measured clinically as a predictor of glomerular filtration rate?
A- Renin
B- Inulin
C- Fructose
D- CreatinineE- Angiotensin
184-Production of phosphoenolpyruvate carboxykinase is stimulated by
A- onsulin
B- cortisol
C- aldostrone
D- somatotropin.
 
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wireless_doc said:
I would pick C for 114.
Click to expand...
i confirmed it from here

Release from adipose tissue
The breakdown of fat stored in fat cells is known as lipolysis. During this process, free fatty acids are released into the bloodstream and circulate throughout the body. Ketones are produced, leading to the process of ketosis in the case where insufficient carbohydrates are present in the diet. Lipolysis testing strips such as Ketostix are available which can sometimes measure whether or not this process is taking place.

The following hormones induce lipolysis: epinephrine, norepinephrine, glucagon and adrenocorticotropic hormone. These trigger 7TM receptors, which activate adenylate cyclase. This results in increased production of cAMP, which activates protein kinase A, which subsequently activate lipases found in adipose tissue.

Triglycerides undergo lipolysis (hydrolysis by lipases) and are broken down into glycerol and fatty acids. Once released into the blood, the free fatty acids bind to serum albumin for transport to tissues that require energy. The glycerol backbone is absorbed by the liver and eventually converted into glyceraldehyde 3-phosphate (G3P), which is an intermediate in both glycolysis and gluconeogenesis.

[edit]
Activation and transport into mitochondria
Fatty acids must be activated before they can be carried into the mitochondria, where fatty acid oxidation occurs. This process occurs in two steps:
 
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118-Which of the following represents the principle allosteric regulator of pyruvate metabolism in the liver?
A- ATP
B- NAD
C-citrate
D-cyclic AMP
E-Acetyl CoA

i think it is E
 
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mouth mirror said:
118-Which of the following represents the principle allosteric regulator of pyruvate metabolism in the liver?
A- ATP
B- NAD
C-citrate
D-cyclic AMP
E-Acetyl CoA

i think it is E
Click to expand...
even i think but do you think it is due to increased actylcoA combination of pyruvate or is there any other explanation??
 
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128-Which of the following statements BEST describes the activity of DNA ligase?
A- seals single-stranded nicks in DNA.
B- proofreads the DNA proper base paring.
C- prevents the polymerase from falling off the DNA.
D- Removes the RNA primer from the lagging strand.


My answer goes with A.
Reason : Single-stranded nicks in DNA can be repaired by DNA polymerase but the polymerase still need DNA ligase to create phosphodiester bond for complete repair.
 
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any more comment on the following answers please?

114-Methyl xanthines such as caffeine and theophylline enhance lipolysis in adipose tissue by:
A- induced adenylate cyclase synthesis.
B- induced triglyceride lipase synthesis.
C- inhibiting cyclic AMP phosphodiestrase activity.
D- directlyactivating an interacellularprotein kinase.
E- enhancing the binding of epinephrine to an extracellular membrane receptor.
C

115-Which of the following can increase the rate of net flux or diffusion of oxygen through the alveolar membrane?
A- Decreasing temprature
B- Increasing the cross-sectional area
C- Decreasing the concentration gradient
D- Increasing the path length of diffusion
B
118-Which of the following represents the principle allosteric regulator of pyruvate methabolism in the liver?
A- ATP
B- NAD
C-citrate
D-cyclic AMP
E-Acetyl CoA
E

128-Which of the following statements BEST describes the activity of DNA ligase?
A- seals single-stranded nicks in DNA.
B- proofreads the DNA proper base paring.
C- prevents the polymerase from falling off the DNA.
D- Removes the RNA primer from the lagging strand.
A

147-Which of the following represents the sensory organs concerned with maintenance of skeletal muscle tonus?
A- sarcomeres
B- Muscle spindles
C- Gamma efferents
D- Pacinian corpuscles
E- Golgi tendon organs
E

159-Which of the following functional group are essential for a substance to act as a amphipathic (amphiphilic) molecule?
A- Polar, nonpolar
B- Polar, negatively charged
C- Nonpolar, positively charged
D- Cyclic, hydrophilic
E- Branched, Hydrophilic
A

162-which of the following natural metabolism measured clinically as a predictor of glomerular filtration rate?
A- Renin
B- Inulin
C- Fructose
D-Creatinine
E- Angiotensin
D

183-Which of the following represents the compound that contains an active (labile) methyl group?
A- Serine
B- Creatine
C- Methionine
D- S-adenosyl methionine
D

184-Production of phosphoenolpyruvate carboxykinase is stimulated by
A- onsulin
B- cortisol
C- aldostrone
D- somatotropin.
B

Thanks again for the contribution.[/QUOTE]
 
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140. A 0.2 mole/liter Nacl solution and a 0.2 mole/liter glucose solution are separated by a membrane that is impermeable to these solutes but is permeable to water. which of the following statements is correct?
A. There will be no net movement of water to either solution.
B. Water will go from the glucose to the saline solution.
C. Water will go from the saline to the glucose solution.
D. Concentration of glucose will decrease.
E. Concentration of Nacl will increase.

170. A single impulse travels down an alpha motor axon. this results in which of the following?
A. The activation of a single motor unit
B. The contraction of one muscle fiber
C. A subthreshold generator potential
D. A muscle action potential without contraction
E. Brief repetitive firing of muscle fibers.

178. Excessive use of diuretics leads to which of the following conditions?
A. Metabolic alkalosis
B. Respiratory alkalosis.
C. Metabolic acidosis.
D. Respiratory acidosis.
 
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[
178. Excessive use of diuretics leads to which of the following conditions?
A. Metabolic alkalosis
B. Respiratory alkalosis.
C. Metabolic acidosis.
D. Respiratory acidosis.[/QUOTE]]
i think it is A
 
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140. A 0.2 mole/liter Nacl solution and a 0.2 mole/liter glucose solution are separated by a membrane that is impermeable to these solutes but is permeable to water. which of the following statements is correct?
A. There will be no net movement of water to either solution.
B. Water will go from the glucose to the saline solution.
C. Water will go from the saline to the glucose solution.
D. Concentration of glucose will decrease.
E. Concentration of Nacl will increase.
C
 
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140 are you sure about this coz i thought water goes where nacl goes so it has to be glucose to saline
178 even in this as excess diuretics is used more of urine with inorganic materials go out so it has to be metabolic acidosis ,
170 a pls do correct me if wrong
the more you study the more you get confused , this is becoming a problem for me what about every one else........
 
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Ruchig said:
140. A 0.2 mole/liter Nacl solution and a 0.2 mole/liter glucose solution are separated by a membrane that is impermeable to these solutes but is permeable to water. which of the following statements is correct?
A. There will be no net movement of water to either solution.
B. Water will go from the glucose to the saline solution.
C. Water will go from the saline to the glucose solution.
D. Concentration of glucose will decrease.
E. Concentration of Nacl will increase.
C
Click to expand...

Hi. I am a little confused with that question. I think the answer should be A because the molarities of the solutions are the same and the process is osmositc movement. Both solutions have equal no. of solute and so there should be no net movement. Could u guys explain me ur reasons?
 
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dentethic said:
140. A 0.2 mole/liter Nacl solution and a 0.2 mole/liter glucose solution are separated by a membrane that is impermeable to these solutes but is permeable to water. which of the following statements is correct?
A. There will be no net movement of water to either solution.
B. Water will go from the glucose to the saline solution.
C. Water will go from the saline to the glucose solution.
D. Concentration of glucose will decrease.
E. Concentration of Nacl will increase.
A

170. A single impulse travels down an alpha motor axon. this results in which of the following?
A. The activation of a single motor unit
B. The contraction of one muscle fiber
C. A subthreshold generator potential
D. A muscle action potential without contraction
E. Brief repetitive firing of muscle fibers.
C
178. Excessive use of diuretics leads to which of the following conditions?
A. Metabolic alkalosis
B. Respiratory alkalosis.
C. Metabolic acidosis.
D. Respiratory acidosis.
Click to expand...
A
 
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Can anybody explain me. As far as I know 1M Nacl is not equal to 1 M glucose because both have different osmotic pressure. NaCl can ionize into 2 particles but glucose cant split into two or more particles.
Does O.P matters in movement of solvent in a solution?
 
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Ruchig said:
Can anybody explain me. As far as I know 1M Nacl is not equal to 1 M glucose because both have different osmotic pressure. NaCl can ionize into 2 particles but glucose cant split into two or more particles.
Does O.P matters in movement of solvent in a solution?
Click to expand...

water moves from solution of low osmolarity to the higher so as to maintain equilibrium.membrane is only permeable to water,so no net movt. of water,as both systems in equilibrium
 
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Hi Ruchig!
The solutions have the same osmotic pressure because they have the same number of solute particles. It does not depend on the size or the molecular wt. And we are not splitting any molecules. During osmosis, water(solvent) will go from the side with lesser particles to the side with more particle to reach the osmotic equilibrium. That's what I have learned. Hope this answer your question.
 
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Below is the information I read from DD 2006 phys/bioc (misc)
Q which of the following has osmotic pressure different from other two solution?
1 M glucose
1 M nacl
1 M kno3
Answer is 1m glucose
Reasoning mentioned:
the key to the solution is that Osmotic pressure of a solution depends on number of solutes particles present and not various properties.nacl and kno3 will ionize into two ions per molecule, wheras glucose will remain as a single molecule in a solution.
Osmotic pressure is the pressure that develops in a solution as a result of net osmosis;it is affected by number of dissolved particles per unit volume of fluid.
I am still confused?????????????????
 
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Ruchig said:
Below is the information I read from DD 2006 phys/bioc (misc)
Q which of the following has osmotic pressure different from other two solution?
1 M glucose
1 M nacl
1 M kno3
Answer is 1m glucose
Reasoning mentioned:
the key to the solution is that Osmotic pressure of a solution depends on number of solutes particles present and not various properties.nacl and kno3 will ionize into two ions per molecule, wheras glucose will remain as a single molecule in a solution.
Osmotic pressure is the pressure that develops in a solution as a result of net osmosis;it is affected by number of dissolved particles per unit volume of fluid.
I am still confused?????????????????
Click to expand...

can anybody explain this???
 
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is there 9 essential amino acid or 10 , 2004 deck says there are 9 but kaplan says there are 10 including arginine .........now what is correct
 
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dentethic said:
140. A 0.2 mole/liter Nacl solution and a 0.2 mole/liter glucose solution are separated by a membrane that is impermeable to these solutes but is permeable to water. which of the following statements is correct?
A. There will be no net movement of water to either solution.
B. Water will go from the glucose to the saline solution.
C. Water will go from the saline to the glucose solution.
D. Concentration of glucose will decrease.
E. Concentration of Nacl will increase.

170. A single impulse travels down an alpha motor axon. this results in which of the following?
A. The activation of a single motor unit
B. The contraction of one muscle fiber
C. A subthreshold generator potential
D. A muscle action potential without contraction
E. Brief repetitive firing of muscle fibers.

178. Excessive use of diuretics leads to which of the following conditions?
A. Metabolic alkalosis
B. Respiratory alkalosis.
C. Metabolic acidosis.
D. Respiratory acidosis.
Click to expand...

i have some questions if you could answer these please
cell membarane is least permeabe to
water
sodium
oxygen
ehanol
glycerol
 
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swetha_dentist said:
can anybody explain this???
Click to expand...

i also want the explaination of the above.
then the other question is 1. eash of the following polmers is correctly paireswith an activated recursor except one
1.sucrose-dextran
2.glucose-glycogen
3. sucrose-mutan
4.udp glu-glycogen
5sucrose-levan
 
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swetha_dentist said:
can anybody explain this???
Click to expand...

A.in addition to final product of metabolism carbondioxide is required as a substrate for ann enzyme that is assosiated with 1. biosynthesis of fatty acids from glycerol
2.biosynthesis of ribose 5 phosphate from glucose.
3.oxidation of acetyl coa by the citric acid cycle
4. generation of atp during mitochondrial oxidation of nadh
B.in which of the the following conditions is oxygen partial preasure low inn the arterial blood
1.anemia
2.polycythemia
3pulmonary av shunt
4 hypovolemia due to hemorrhage
 
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kareena said:
A.in addition to final product of metabolism carbondioxide is required as a substrate for ann enzyme that is assosiated with 1. biosynthesis of fatty acids from glycerol,i think this is the answer.
B.in which of the the following conditions is oxygen partial preasure low inn the arterial blood
1.anemia
2.polycythemia
3pulmonary av shunt
4 hypovolemia due to hemorrhage
Click to expand...
1 /4??

kareena i think you have added my post with out your knowledge plz check,thanks
 
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I Would Appreciate If Somebody Could Please Look Into The Questions That I Postedand Answer Them.
 
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kareena said:
i have some questions if you could answer these please
cell membarane is least permeabe to
water
sodium
oxygen
ehanol
glycerol
Click to expand...

i think its glycerol
it cannot be oxygen,water,oxygen............compared to ethanol and glycerine they are more permeable

now.i think glycerol is not permeable through membrane
 
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