PAS stain

[SearedTuna]

I know that PAS stain indicates presence of glycoprotein which is present in t whippelii and can also be a marker for arylsulfatase, but what other main things come to mind when you hear PAS positive? thanks in advance!

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[illinichief89]

Extramammary Paget disease is PAS+

 

[canary90]

hepatocytes are PAS+ve in alpha 1 antitrypsin deficiency

 

[Pholston]

It stains basement membrane, glycogen, mucins and mucopolysaccharides (various inclusions, bodies, granules and secretions composed of mucopolysaccharides or mucins).

Breast cytology: atypical cells, correlate with malignant histology
Fungi: stains fungal cell walls
Hematopathology: ALL, AML M5-M7
Kidney: routine evaluation of renal biopsies due to basement membrane staining; also useful to diagnose renal cell carcinoma
Liver: inclusions of alpha-1-antitrypsin deficiency
Lung: pulmonary alveolar proteinosis
Muscle biopsies: glycogen
Pancreas: acinar cell carcinoma
Parotid glands: zymogen granules
Small intestine: Whipple’s disease
Testis: germ cell neoplasia
Tumors: adenocarcinoma of various sites (mucin)