path question

[konquer]

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What kind of necrosis would a spider bite cause? My answer is liquefaction necrosis since the immune system would be activated leading to pus formation. But UW explanation is coagulate necrosis.

Can anyone please explain how is this possible despite lack of hypoxia?

 

[MedLover25]

What kind of necrosis would a spider bite cause? My answer is liquefaction necrosis since the immune system would be activated leading to pus formation. But UW explanation is coagulate necrosis.

Can anyone please explain how is this possible despite lack of hypoxia?

Hypoxia and liquefactive necrosis has to do with the CNS. In other cases it leads to coagulative.

Also, I think you're confusing your definitions. Pus formation is caseous necrosis, not liquefactive. I also don't believe the spider bite in that question leads to pus formation either.

It also might help to actually read what UW says, and not just what the answer is (I believe I remember that question, I thought they explained it)

 

[Richspiders07]

Hypoxia and liquefactive necrosis has to do with the CNS. In other cases it leads to coagulative.

Also, I think you're confusing your definitions. Pus formation is caseous necrosis, not liquefactive. I also don't believe the spider bite in that question leads to pus formation either.

It also might help to actually read what UW says, and not just what the answer is (I believe I remember that question, I thought they explained it)

👍 I never answer/think liq. necr. unless something is goin on in the brain

 

[rabbitsfeet777]

I wouldn't completely go by that actually. A wound abscess from Clostridium perf would be considered liquifactive necrosis...hence "wet gangrene."

 

[Mortal_Lessons]

I wouldn't completely go by that actually. A wound abscess from Clostridium perf would be considered liquifactive necrosis...hence "wet gangrene."

Also, dry gangrene (coagulative necrosis) that becomes secondarily infected can morph into wet gangrene (liquefactive necrosis).

 

[mrmandrake]

Also, I think you're confusing your definitions. Pus formation is caseous necrosis, not liquefactive. I also don't believe the spider bite in that question leads to pus formation either.

Pus formation is actually associated with liquefactive necrosis (page 17 of big robbins pathology). But I concur that you can't assume a spider bite will lead to pus formation.

 

[mrmandrake]

What kind of necrosis would a spider bite cause? My answer is liquefaction necrosis since the immune system would be activated leading to pus formation. But UW explanation is coagulate necrosis.

Can anyone please explain how is this possible despite lack of hypoxia?

Knowing the answer given probably helps but when you think of liquefactive necrosis, think brain, cns, bacterial or fungal infection. You can't assume any of those 4 conditions with a spider bite (unless there is more info in the question than you posted), so you pretty much have coagulative left.

Coagulation necrosis does not have to occur via hypoxia, although I think that's the leading cause. The primary pattern is denaturation and coagulation of proteins of the cytoplasm, leaving the structure intact.