Pathology of different types of rejections

[Pril]

---

Members don't see this ad.

Can anyone explain the difference pathologically especially in relation to arteries supplying the Kidney in
Hyperacute Rejection
Acute "
Chronic "
I understand the time and the immunological components involved like preformed IGg in Hyperacute and so forth but what's confusing me is the process in the renal arteries in all three it seems the same. (there was several questions in the pathology shelf about this topic)

 

[Kalel]

I think the reason that you are getting confused is because in chronic rejection, there are still elements on acute rejection going on that can be observed pathologically. Some theorize that chronic rejection is just an extension of acute rejection that occurs chronically and on a smaller scale. The exact mechanism of chronic rejection isn't known, and both can/do cause obliteration of renal arterieral lumens, but you may be able to see more long-term changes in chronic rejection like intimal fibrosis, more loss of renal tubules with sclerosis, and replacement with fibrous connective tissue that you may not observe with acute rejection. Here's a good website that I was able to find on the subject:
http://peir.path.uab.edu/iplab/messages/598/487.html?ThursdayMarch820010322pm