Jul 6, 2016
10
0
Pg 356 FA2016 says NSAIDs decrease PGE2 --> decrease gastric mucosa protection

We know misoprostol (PGE1 analog) is used to counteract NSAID mucosal impairment. Is it PGE1 or PGE2 that maintains healthy mucosa?
 
Last edited:

das0088

2+ Year Member
May 3, 2016
7
1
Status
MD/PhD Student
cox1 for healthy mucosa and cox2 for inflammation

PGE1 for decrease vascular tone and keeping PDA open
PGE2 for increasing uterine tone, abortificant
 
Last edited:
Jul 2, 2016
18
5
Status
Medical Student
Yes, PGE2 protects gastric mucosa.
PGE2 has 4 receptors (EP1, EP2, EP3 and EP4). Misoprostol, which is a PGE1 analogue, is an EP3 agonist (EP3 inhibits gastric acid secretion and increases gastric mucus production).
(source: LWW pharmcards)