M med217 New Member 7+ Year Member Joined Jul 6, 2016 Messages 10 Reaction score 0 Points 0 Jul 26, 2016 #1 Advertisement - Members don't see this ad Pg 356 FA2016 says NSAIDs decrease PGE2 --> decrease gastric mucosa protection We know misoprostol (PGE1 analog) is used to counteract NSAID mucosal impairment. Is it PGE1 or PGE2 that maintains healthy mucosa? Last edited: Jul 26, 2016
Advertisement - Members don't see this ad Pg 356 FA2016 says NSAIDs decrease PGE2 --> decrease gastric mucosa protection We know misoprostol (PGE1 analog) is used to counteract NSAID mucosal impairment. Is it PGE1 or PGE2 that maintains healthy mucosa?
D das0088 New Member 7+ Year Member Joined May 3, 2016 Messages 7 Reaction score 1 Points 4,551 MD/PhD Student Jul 27, 2016 #2 cox1 for healthy mucosa and cox2 for inflammation PGE1 for decrease vascular tone and keeping PDA open PGE2 for increasing uterine tone, abortificant Last edited: Jul 28, 2016 Upvote 0 Downvote
cox1 for healthy mucosa and cox2 for inflammation PGE1 for decrease vascular tone and keeping PDA open PGE2 for increasing uterine tone, abortificant
I IMG217 Full Member 7+ Year Member Joined Jul 2, 2016 Messages 18 Reaction score 5 Points 4,581 Medical Student Aug 1, 2016 #3 Yes, PGE2 protects gastric mucosa. PGE2 has 4 receptors (EP1, EP2, EP3 and EP4). Misoprostol, which is a PGE1 analogue, is an EP3 agonist (EP3 inhibits gastric acid secretion and increases gastric mucus production). (source: LWW pharmcards) Upvote 0 Downvote
Yes, PGE2 protects gastric mucosa. PGE2 has 4 receptors (EP1, EP2, EP3 and EP4). Misoprostol, which is a PGE1 analogue, is an EP3 agonist (EP3 inhibits gastric acid secretion and increases gastric mucus production). (source: LWW pharmcards)
