Pharmacology

[Venkatcpp]

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hey,
could anyone please help me with this.

why is the use of vasoconstictors in combination with local anesthetics contraindicated in a patient with Parkinson disease who is on levodopa.

thanks a ton

 

[Sinatra Frank]

hey,
could anyone please help me with this.

why is the use of vasoconstictors in combination with local anesthetics contraindicated in a patient with Parkinson disease who is on levodopa.

thanks a ton

levodopa is a prodrug.. it serves as a substance for dopaine synthesis.
pts with parkinson has low dopaminergic neurons..so taking this drug will increase dopamine conc.

the thing is that l-dopa is not being utilized solely in the brain but also in the periphery before it crosses the BBB..high conc of dopamine in the blood cause vasoconstriction and this is the reason,we dont want to cause excessive vasoconstriction..

 

[Venkatcpp]

thankyou very much Sinatra Frank...
i appreciate it...

 

[Sinatra Frank]

thankyou very much Sinatra Frank...
i appreciate it...

hi..
your welcome.
this question is for nbde part 1 or 2?

 

[Venkatcpp]

hi..
your welcome.
this question is for nbde part 1 or 2?

thats a part2 question.