Pharmacy references

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bluesky0912

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10+ Year Member
Hello everyone,

I am a new graduate and working at retail. I have got several questions about how long a drug kicks in and how long it eliminates from the body. Could you please tell me where I can find info to support my answers?
Thank you
 
bluesky0912 said:
Hello everyone,

I am a new graduate and working at retail. I have got several questions about how long a drug kicks in and how long it eliminates from the body. Could you please tell me where I can find info to support my answers?
Thank you
Click to expand...

clinical pharmacology or lexi complete under pharmacokinetics .
 
Is this for real? A person spends 4 years in pharmacy school, graduates, gets licensed, is working as an RPH, and has to ask a message board on the internet to answer these questions? Hey
OP you might want to start by looking at a packge insert.
 
Hello everyone,

Thank you for all your input esp. nice ancienbon's response. I know after 4-5 T1/2, drug elimination is considered complete, but T1/2 is not always provided in clinical pharmacology.

I would like learn experience from seniors to provide accurate answers for my patients.

Please use professional words. Thanks
 
bluesky0912 said:
I would like learn experience from seniors to provide accurate answers for my patients.
Click to expand...

you mean like pharmacy school seniors?


seriously...finding this stuff was one of the first things taught in school, i'm appalled at this is an actual question on the forum by a practitioner. I'd expect this from a pre-pharm or maybe even a first year student, but not someone who actually is on the front lines....

just my thought. and to complete this answer: check lexi-comp. cue thread on how to obtain lexi-comp.
 
bluesky0912 said:
Hello everyone,

I am a new graduate and working at retail. I have got several questions about how long a drug kicks in and how long it eliminates from the body. Could you please tell me where I can find info to support my answers?
Thank you
Click to expand...


Just curious. What school did you graduate from?
 
Are new schools these days not teaching sources of drug information? I remember the professor I had telling us that it would be the most useful class we ever took...she was right, of course. No pharmacist can remember everything, but they should come out of pharmacy school being able to research basic drug questions.
 
bluesky0912 said:
Hello everyone,

I am a new graduate and working at retail. I have got several questions about how long a drug kicks in and how long it eliminates from the body. Could you please tell me where I can find info to support my answers?
Thank you
Click to expand...

I have access to Clinical Pharmacology in the retail setting where I work. Ask your fellow RPhs at work where you can find these types of resources if you can't find them yourself.

I use Lexi-Comp (need to pay for access) & Micromedex (free) apps on my phone, and both provide pharmacokinetic information. Also, like others have already mentioned, grab the package inserts to get all kinds of info from storage to dosage forms to kinetics <-- had to do this when a woman was arguing with me why I didn't give her Vyvanse in blister-packs, and I said I've never seen it in that manner - called the rep to confirm that she was wrong, heh
 
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confettiflyer said:
you mean like pharmacy school seniors?


seriously...finding this stuff was one of the first things taught in school, i'm appalled at this is an actual question on the forum by a practitioner. I'd expect this from a pre-pharm or maybe even a first year student, but not someone who actually is on the front lines....

just my thought. and to complete this answer: check lexi-comp. cue thread on how to obtain lexi-comp.
Click to expand...

Completely agree. Try reading a package insert. And how did you graduate without knowing where to find half lives and such?
 
i'll have to agree with the consensus
it's pretty damn alarming that the OP is a pharmacist and doesn't know where to look for pharmacy information. it's one thing to not know information about a drug, but a whole other level of fail to not even know where to look it up.
one of my friends went to a pharmacy to get something for a soaking aid for her tired feet. she picked up epzom salt and asked the pharmacist if she could use it. the pharmacist(which according to my friend looked fresh out of college) read the label for a minute and told her it was only for laxatives.
 
thephoenician88 said:
so OP when the patient asked you how long it would take to kick in, what did you say?

HMMMM I DON'T REMEMBER?????
Click to expand...



Please, please, please, folks, when the patient asked how long it would take to kick in, sometimes, it's hard to answer.

Pharmacokinetic can prove with numbers the time we find Peak Concentration of drug in blood. But, the Moment we see peak concentration of drug in blood or Moment to see Steady State does not mean the Moment the drug is helpful.
For example, starting NEW Birth Control, in general, Moment of finding Peak Concentration can be expected to be within a day. But, the first 7 days has no help yet because REAL PROTECTION will happen in 1 week. In the first week, must use condom or other ways to prevent pregnancy. So, for starting NEW Birth Control, the kick in time is 1 week. Not shown in pharmacokinetic. But, side effect of nausea can be felt within a few hours.

For example, starting NEW anti-depressant, in general, Moment of finding Peak Concentration can be expected to be within a day. But, we beg the patient to keep taking pills for over 1 week or 2 weeks then patient will feel full effect of having less depression, meaning kick in will happen in 1 week or 2 weeks. But, side effect of sleepiness or sleeplessness may happen within a day.

For example, Starting NEW anti-biotic, in general, Moment of finding Peak Concentration can be expected to be within a day. But, we beg the patient to keep taking pills for 48 hours to fully see the effectiveness of the anti-biotic that this anti-biotic weapon matches this bacteria.

For the patient, they don't care about the Moment of finding Peak Concentration that we see in pharmacokinetic.
Our sick patients care about the time they START TO FEEL BETTER. We need a section that has range of TIME TO SEE EFFECTIVENESS.

Please, someone share with us:
Yaz: Where would the database show when patient will ACTUALLY GET HELP? Our school taught us: about 1 week. I found that under counseling, not pharmacokinetic.

Folks,
Below is the data I would like to see reported in drug database readily for community pharmacist to help patients:
Source: Clinical Pharmacology (under Fair Use License):
"In children, the antipyretic effect of oral therapy begins within 1 hour and peaks within 2—4 hours.

The analgesic effect is similarly acute in nature.

In treatment for inflammation, a few days to 2 weeks is generally required before a therapeutic response occurs."

How about Duloxetine, which has "Steady-state concentrations typically occur after 3 days of dosing.", but under Administration, I found this data mixed in sentences:
"...reduction in mean pain scores, was significant by the end of week 1."

"A response to treatment, defined as a 30% reduction from baseline in 24-hour average pain severity on a 0—10 scale, occurred in 63% of patients in the 60 mg/day group and 42% of patients receiving placebo."

That's what I like to find in database READILY, under 1 special section called: TIME TO SEE EFFECTIVENESS. Why? How about the time when I have 30 seconds at community pharmacy to help a patient in pain at the register and refusing to leave my pharmacy, with 4 phone lines ringing and on hold, and kids crying, plus 1 doctor waiting to give new prescriptions and about 10 patients waiting to pickup? (sorry for the long sentence)

Can someone start a new revolution for drug database?

Thank you very much for your help.
 
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bluesky0912 said:
Hello everyone,

I am a new graduate and working at retail. I have got several questions about how long a drug kicks in and how long it eliminates from the body. Could you please tell me where I can find info to support my answers?
Thank you
Click to expand...

where did you go to school?
 
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