That's not an easy question to answer because of the subjectivity of the question. It all comes down to personal choice. Some find it easier and like it more in a hospital or at a major chain. It all depends on you and what you will like or put up with. You won't know until you try it. A lot of it comes down to company policy and the people you work with.
For the most part, chain stores such as CVS and Walgreens will fill more scripts than your local grocery store. You will have less "work" to do, but keep in mind you will also have less technician help than in a chain store.