Phosphatase vs Hydrolase : GTPase

[deleted612812]

Hey can anyone put in clear terms what the difference between a hydrolase and a phosphatase is ?

And also why is GTPase (GTP --> GDP) a hydrolase and not a phosphatase

Thanks!!!!

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[Necr0sis713]

Hydrolase because you're hydrolyzing the GTP to make GDP and phosphate.

Phosphatase is for taking a phosphate off of stuff, like off of organic molecules other than dNTPs

 

[PreMedChemE]

A Hydrolase also uses water:
hydrolase: A–B + H2O → A–OH + B–H.
So GTP +H2O -> GDP +P

But GTPase is both a hydrolase and phosphatase. But make sure you aren't confusing phosphatase with a phosphorylase, which removes a phosphate but without water.

A Hydrolase doesn't always remove a phosphate, but in this case it does.

A phosphatase is a type of hydrolase, though.

"Hydrolases are classified as EC 3 in the EC number classification of enzymes. Hydrolases can be further classified into several subclasses, based upon the bonds they act upon:

• EC 3.1: ester bonds (esterases: nucleases, phosphodiesterases, lipase, phosphatase)" - From wikipedia

 

[Dr. Trenb]

http://www.fastbleep.com/biology-notes/40/116/1159