Plasma Esterase/Pseudo Cholinesterase

[SleepIsGood]

So with the ITE tommorrow. Point of confusion to clarify:

Plasma esterase metabolism occurs for: Remifent, Esmolol, and ester local anesthetics.

pseudocholinesterase for metabolism of : Mivacurium and Sux right?

I know there are no K types, but on a ABA retired Q, there's a question about A pt was given sux and then had no twitches 20 min later. What drugs should be avoided?
1)cocaine
2)Remi
3)Mivacurium
4)Esmolol

Dont know the answer....lost the key.
The K types are like below (if you forgot..ahhaha I did)
A=1,2,3
B=1,3
C=2,4
D=4

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[Jeff05]

So with the ITE tommorrow. Point of confusion to clarify:

Plasma esterase metabolism occurs for: Remifent, Esmolol, and ester local anesthetics.

pseudocholinesterase for metabolism of : Mivacurium and Sux right?

I know there are no K types, but on a ABA retired Q, there's a question about A pt was given sux and then had no twitches 20 min later. What drugs should be avoided?
1)cocaine
2)Remi
3)Mivacurium
4)Esmolol

Dont know the answer....lost the key.
The K types are like below (if you forgot..ahhaha I did)
A=1,2,3
B=1,3
C=2,4
D=4

esters are metabolized by pseudocholinesterase, as well.
http://books.google.com/books?id=qV... pseudocholinesterase succinylcholine&f=false

esmolol is metabolized by RBC esterases.

remi is metabolized by non-specific plasma esterases.

so the answer would be B.

 

[pgg]

Dont know the answer....lost the key.

Keys for the 1990 - 1996 exams are available here.

 

[SleepIsGood]

esters are metabolized by pseudocholinesterase, as well.
http://books.google.com/books?id=qV... pseudocholinesterase succinylcholine&f=false

esmolol is metabolized by RBC esterases.

remi is metabolized by non-specific plasma esterases.

so the answer would be B.

I agree with you the answer is B. However, when I read through some of Jensen's stuff, it seemed to suggest ester anesthetics are also prohibited if you have a pseudocholinesterase def. Thanks for reassuring that's NOT the case.

 

[ProRealDoc]

I agree with you the answer is B. However, when I read through some of Jensen's stuff, it seemed to suggest ester anesthetics are also prohibited if you have a pseudocholinesterase def. Thanks for reassuring that's NOT the case.

Cocaine is an ester anesthetic so it would be contraindicated in a pt with pseudocholinesterase deficiency as would mivacurium.

 

[Jeff05]

I agree with you the answer is B. However, when I read through some of Jensen's stuff, it seemed to suggest ester anesthetics are also prohibited if you have a pseudocholinesterase def. Thanks for reassuring that's NOT the case.

that was exactly NOT my point. esters ARE metabolized by pseudocholinesterase and you should therefore be cautious in a deficiency.

 

[SleepIsGood]

that was exactly NOT my point. esters ARE metabolized by pseudocholinesterase and you should therefore be cautious in a deficiency.

sorry yes that's what i meant.....too much studying..eyes are going sleeeeeepy