In 2018, during my first year out of fellowship, I performed a caudal ESI using a 25-gauge, 1.5-inch needle on an 89-year-old woman on Plavix. At the time, my much more experienced physician employer had been doing caudals with this size needle on elderly patients while continuing anticoagulation for years and convinced me to as well. The patient developed an L2-3 epidural hematoma. My thoughts on the mechanism of action was that the patient likely had a friable venous plexus in the epidural space and the pressure from the 10 cc of medication I injected caused a small tear in one of these veins at that level. The Plavix did the rest. Just sharing as a cautionary tale. I have not performed an ESI on a patient on anticoagulation since that experience.