Polyarteritis Nodosa...is it associated with P-ANCA?

[DOCTORSAIB]

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I am thoroughly confused. I've been using BRS path while studying for my path exams. In BRS, it says polyarteritis nodosa IS associated with P-ANCA. Big robbins says its NOT and our path professor says its NOT. 2005 FA says its NOT but now the new *updated* 2005 errata sheet says polyarteritis nodosa "can be associated with P-ANCA."

I want the truth! (please dont reply with "you can't handle the truth!")

 

[Boomer]

I am thoroughly confused. I've been using BRS path while studying for my path exams. In BRS, it says polyarteritis nodosa IS associated with P-ANCA. Big robbins says its NOT and our path professor says its NOT. 2005 FA says its NOT but now the new *updated* 2005 errata sheet says polyarteritis nodosa "can be associated with P-ANCA."

I want the truth! (please dont reply with "you can't handle the truth!")

Harrison's 15th ed. pg 1957

"p-ANCAhave been reported to occur in variable percentages of patients with microscopic polyangiitis, polyarteritis nodosa, Churg-Strauss syndrome..."

pg 1959

"Positive ANCA titeres (usually of the p-ANCA type) are found in a low percentage (<20%) of patients with classic PAN."


Clear as mud, eh?

 

[DOCTORSAIB]

Harrison's 15th ed. pg 1957

"p-ANCAhave been reported to occur in variable percentages of patients with microscopic polyangiitis, polyarteritis nodosa, Churg-Strauss syndrome..."

pg 1959

"Positive ANCA titeres (usually of the p-ANCA type) are found in a low percentage (<20%) of patients with classic PAN."


Clear as mud, eh?

Boomer,

Thats one place I didn't look, Harrisons. I wonder why there's such a discrepancy between major texts, Robbins vs. Harrisons.

If anyone else can prove otherwise, please feel free to reply.

 

[caribsun]

this has been discussed...search for the thread.
PANCA is associated with polyarteritis nodosa, but it is not specific for it, so you can't make a diagnosis based on it.

 

[Janders]

this has been discussed...search for the thread.
PANCA is associated with polyarteritis nodosa, but it is not specific for it, so you can't make a diagnosis based on it.

Exactly!

I don't think this is a big deal. There is a loose association, so the texts vary a bit, depending on when they were published and who wrote that chapter. I'm sure any question that might come up on the Boards would take this into account. If not, no biggie, its one question. Just always be on the look out for the "best" answer.