I recommend enrolling at a local 4 year university to take classes. Depending on the school, your friend may have to declare as a degree seeking student in order to get financial aid (you wouldnt have to finish the degree if you got into dental school). This is called an informal post bac. It's a lot cheaper than a masters and since formal post bac programs are hard to get in (they usually have extra benefits like if you maintain a 3.8GPA you are guaranteed one interview or something like that). If your friend enrolls in an informal post bac, tell him to take upper lvl bio classes especially ones geared towards dental school (immuno, embryology, etc). Make sure he does WELL. Like 3.7+GPA with a full course load every semester. Depending on how low his GPA, this post bac should take about 2 years. Once he wraps that up, he needs to take the DAT and kick the living crap out of it. 21+ AA. In addition to this, he wants to improve all aspects of his application. The general rule I hear is to basically double your shadowing and community service hours. Triple it if it was really low to begin with. Write a strong personal statement describing what he did that he improved on. Finally, tell him to apply early when the time comes like when the application opens.