I think the OP is talking about pharmacy not undergrad. They're both really different in my opinion because in undergrad you can get a scholarship to a private school and not pay anything and still have smaller classes and other benefits that you might prefer over a school with 60,000 students. I went to a medium size private school with about 9-10,000 undergrads so it was still fun.
For pharmacy school you are going to pay more since scholarships (particularly full scholarships) are rare if not non-existent, but it just depends on the individual person. Cost of living in various areas, jobs, whether you love or dislike the area, opportunities (research/etc), curriculum, etc.