Proton beam radiation and airway fibrosis

[Ether Dome]

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Is it possible for proton beam radiation to the orbit for melanoma to cause fibrosis in non-adjacent structures, such as the larynx or trachea?

 

[PhotonBomb]

I mean it depends on the dose those structures got, just like wirh photons

Only difference with protons is the uncertainty of RBE, so if you have proton paths ending in those structures, concern for increased dose is there, but questionable and unclear

 

[seper]

Not possible. I presume you meant choroidal melanoma, which is always treated with a small field.

Is it possible for proton beam radiation to the orbit for melanoma to cause fibrosis in non-adjacent structures, such as the larynx or trachea?

 

[evilbooyaa]

As asked, no, absolutely not. Larynx and trachea dosing would be neglible with treatment of the orbit (regardless of with protons or photons). Would look into other causes. Is patient on immunotherapy?

 

[Radiator20]

Is it possible for proton beam radiation to the orbit for melanoma to cause fibrosis in non-adjacent structures, such as the larynx or trachea?

Would be curious to know the clinical scenario prompting this question, as the answer seems clearly to be no.

Also, for a forum that usually values anonymity, your user name is oddly institution-specific...