@jayquone You'll need to contact the program to ask them this question. My understanding, though, is that most programs (the ones without rolling admissions) set their e-submit deadlines keeping in mind that PTCAS can take 4-5 weeks to process the application from the time of submission. For example, I'm applying to IUPUI in Indianapolis, IN and was told by the head of admissions that the deadline to e-submit (Oct. 1st) is set well in advance of the review date and subsequent interview invites to allow for the PTCAS processing time. Again, though, contact the programs you're applying to.