Papi (goljan) says 2nd to breast cancer, prostate cancer is the most common cancer metastasis to bone.
malignant metastatic cells secrete cytokines that activate osteoblasts. This will lead to bone overgrowth And also result in an increase in ALP since osteoblasts use this in bone formation.
as for PTH. i believe it increases. but couldn't find it anywhere else besides in a section in this research article. interesting but def nothing no brain freeze since this stuff is pretty low-low-yield.
BTW was this an NBME question?
here's the PTH info
Parathyroid Hormone-Related Protein and Endothelin 1
The osteolytic factor parathyroid hormone (PTH)-related
protein (PTHrP) is a homolog of PTH that has a direct
action on PTH receptors, increasing bone resorption and
renal tubular calcium reabsorption.88 In bone metastases,
the release of PTHrP by cancer cells, together with other
factors, contributes significantly to metastatic spread.89,90
PTHrP is abundant in prostate cancer bone metastases,
and in these tumors osteoblastic lesions tend to predominate.
91 One possible explanation for this paradox is that
prostate cancer-derived PTHrP mediates the interactions
between the bone marrow microenvironment and prostate
cancer, which further facilitates the establishment of
skeletal metastases and osteoblastic alterations. Liao et al92
have provided evidence supporting this opinion, reporting
that PTHrP increases osteoblastogenesis-stimulating
osteoblast progenitor cell proliferation and induces early
osteoblast differentiation.
