myry

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Is it good enough to know, for example, that Mirtazapine blocks 5-HT receptors, or do we need to know that it blocks 5-HT2 and 5-HT3 receptors? I see they get more detailed in FA, which surprises me, since we did not cover that in class.:confused:

examples I found:

atypical antipsychotics- 5-HT2 antagonist
buspirone- 5-HT1A agonist
ondansetron- 5-HT3 antagonist
sumatriptan- 5-HT1D agonist
mirtazapine- 5-HT2 and 5-HT antagonist


If we need to know specifics, is there any rhyme and reason to it or just memorize?

Thanks!
 
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myry

myry

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:luck:

trying again...
 

agranulocytosis

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In the course of my studies I've found that lots of pharm questions can get very nitpicky when it comes to their actions at different 5-HT receptors, so I would know them. Also, whatever's in FA is fair game in my books. As far as drugs are concerned, only agonists act at 5-HT1 receptors. All other drugs acting at 5-HT receptors like 5-HT2 and 5-HT3 are antagonists.
 
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myry

myry

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sounds good...thanks so much :)