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question about 5-HT receptor agonists and antagonists

Discussion in 'Step I' started by myry, May 9, 2008.

  1. myry

    myry countdown
    7+ Year Member

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    Is it good enough to know, for example, that Mirtazapine blocks 5-HT receptors, or do we need to know that it blocks 5-HT2 and 5-HT3 receptors? I see they get more detailed in FA, which surprises me, since we did not cover that in class.:confused:

    examples I found:

    atypical antipsychotics- 5-HT2 antagonist
    buspirone- 5-HT1A agonist
    ondansetron- 5-HT3 antagonist
    sumatriptan- 5-HT1D agonist
    mirtazapine- 5-HT2 and 5-HT antagonist


    If we need to know specifics, is there any rhyme and reason to it or just memorize?

    Thanks!
     
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  3. myry

    myry countdown
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    :luck:

    trying again...
     
  4. agranulocytosis

    Physician 10+ Year Member

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    In the course of my studies I've found that lots of pharm questions can get very nitpicky when it comes to their actions at different 5-HT receptors, so I would know them. Also, whatever's in FA is fair game in my books. As far as drugs are concerned, only agonists act at 5-HT1 receptors. All other drugs acting at 5-HT receptors like 5-HT2 and 5-HT3 are antagonists.
     
  5. myry

    myry countdown
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    sounds good...thanks so much :)
     

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