Question about Bio Cascades

[jwnichols21]

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In Destroyer there was a question about cascades, and it said that epinephrine, glucagon, nerve growth factor, and epidermal growth factor were all capable of causing a biochemical cascade. Does this mean that pretty much all hormones can do this? How do we know which do and which don't? Thanks.

 

[crax]

In Destroyer there was a question about cascades, and it said that epinephrine, glucagon, nerve growth factor, and epidermal growth factor were all capable of causing a biochemical cascade. Does this mean that pretty much all hormones can do this? How do we know which do and which don't? Thanks.

no, not all hormones do this. possibly just familiarize yourself with some of the popular cascades. For example ADH is a hormone that does not exhibit a casecade, but is the product of one. renin-angiotensin, thrombin prothrombin fibrinogen , insulin , glucagon, and the thyroid hormone system are some popular cascade like systems that ring a bell. possibly also wikipedia cyclicAMP, adenylcyclase.

i dont think you need to know epi-gf is involved in a cascade

 

[Demps]

Let's keep it simple. I know it is a lot more complicated than what I'm saying but this is enough for DAT-purpose I think.

Ones that causes "cascade" are hydrophilic hormones that needs to bind a receptor on the cell surface to cause a cascade of responses via 2nd messengers. These hormones are often called ligands.

Hydrophobic hormones like steroid-derived hormones do not need to bind a cell-surface receptors because they can simply diffuse through the cell membrane to bind their receptors located in cytoplasm. Binding to their receptor often causes changes in gene expression.

So not all hormones cause "cascade." It depends on which hormone it is.

 

[Demps]

I forgot to mention but all of the hormones that you mentioned - glucagon, epinephrine, NGF, and EGF are all hydrophilic molecules that need to bind their cell-surface located receptors to cause their response.

 

[jwnichols21]

Let's keep it simple. I know it is a lot more complicated than what I'm saying but this is enough for DAT-purpose I think.

Ones that causes "cascade" are hydrophilic hormones that needs to bind a receptor on the cell surface to cause a cascade of responses via 2nd messengers. These hormones are often called ligands.

Hydrophobic hormones like steroid-derived hormones do not need to bind a cell-surface receptors because they can simply diffuse through the cell membrane to bind their receptors located in cytoplasm. Binding to their receptor often causes changes in gene expression.

So not all hormones cause "cascade." It depends on which hormone it is.

This really cleared it up. Thank you very much.