Question about combination drugs.

[vangg]

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So..how do you feel about these drugs formulated together....

1) Lotrisone..I thought a fungal infection could get worst if given a steriod...why the combo then?

2) Mucinex-DM...why are we trying to stop the patient from coughing if we are giving an expectorant?

 

[Praziquantel86]

So..how do you feel about these drugs formulated together....

1) Lotrisone..I thought a fungal infection could get worst if given a steriod...why the combo then?

Rule #3 of dermatology:

1 - If it's wet, dry it.
2 - If it's dry, wet it.
3 - If they're not on a steroid, put 'em on one.
4 - If they're on a steroid, take 'em off.
5 - If it's not supposed to be there, cut the damn thing off.

2) Mucinex-DM...why are we trying to stop the patient from coughing if we are giving an expectorant?

How does dextromethorphan act as a cough suppressant? What does guaifenesin (theoretically) do? Answer those, and then think about it.

 

[Old Timer]

So..how do you feel about these drugs formulated together....

1) Lotrisone..I thought a fungal infection could get worst if given a steriod...why the combo then?

How do steroids effect fungal growth? Answer that and you have answered your question.

2) Mucinex-DM...why are we trying to stop the patient from coughing if we are giving an expectorant?

Do cough suppressants totally suppress the ability to cough?

 

[rph3664]

You should see if you can find a really old PDR (1960s or before) and check out some of THOSE combination products!

Probably the strangest one was Nembu-Serpine. That's right, Nembutal and reserpine, for hypertension. You'd be so zonked, you wouldn't care if you had high blood pressure!

 

[Praziquantel86]

You should see if you can find a really old PDR (1960s or before) and check out some of THOSE combination products!

Probably the strangest one was Nembu-Serpine. That's right, Nembutal and reserpine, for hypertension. You'd be so zonked, you wouldn't care if you had high blood pressure!

Back in the days before Abraham Lincoln and a beaver talked you to sleep...

 

[Old Timer]

Yes, here is my favorite:

Dexamyl Spansule. Dextroamphetamine+amybabrital

 

[rph3664]

How could I forget about Dexamyl? Wasn't that what killed Judy Garland?

How about Marax - theophylline, hydroxyzine, and phenobarbital?

 

[Praziquantel86]

How could I forget about Dexamyl? Wasn't that what killed Judy Garland?

How about Marax - theophylline, hydroxyzine, and phenobarbital?

That sounds like something a kinetics professor with waaaay too much time on his hands came up with.

 

[Old Timer]

That sounds like something a kinetics professor with waaaay too much time on his hands came up with.

Everything you wanted to know about Marax but were afraid to ask.

I was more of a Quadrinal guy.

State of the art asthma care circa 1965:

 

[vangg]

How do steroids effect fungal growth? Answer that and you have answered your question.


Do cough suppressants totally suppress the ability to cough?

Steroids have the ability to suppress your immune system. Thus, allowing the fungus to grow even more. That was my question in the first place.

They do for me. I never recommend the combo since you're not evening coughing out the phlegm you've just loosen. Doesn't make sense. Rather I always suggest mucinex for productive and dextro for nonproductive. Never the combo.

 

[Sparda29]

Steroids have the ability to suppress your immune system. Thus, allowing the fungus to grow even more. That was my question in the first place.

They do for me. I never recommend the combo since you're not evening coughing out the phlegm you've just loosen. Doesn't make sense. Rather I always suggest mucinex for productive and dextro for nonproductive. Never the combo.

Yes, using the steroid portion alone would suppress the immune system and cause a faster spread of the offending organism. However, the combination works differently. The antifungal gets rid of the organism slowly, while the steroid provides rapid relief of the symptoms (itchiness, redness, etc).

If the person only uses the antifungal portion, the infection rash will be a lot more itchy, the person will scratch it a lot more, and probably cause it to spread.

http://www.aafp.org/afp/2002/0515/p2095.html

ANDREW WEINSTEIN, M.D., M.P.H., and BRIAN BERMAN, M.D., PH.D., Topical Treatment of Common Superficial Tinea Infections.University of Miami School of Medicine, Miami, Florida.Am Fam Physician. 2002 May 15;65(10):2095-2103.

As for the Mucinex-DM combo, I don't have any articles about that on hand but personally I don't recommend guafensin at all since drinking H20 is more effective. (My only backup for this is what was on my professors lectures slide.)

 

[Old Timer]

Steroids have the ability to suppress your immune system. Thus, allowing the fungus to grow even more. That was my question in the first place.

Can steroids have this effect when applied topically?

They do for me. I never recommend the combo since you're not evening coughing out the phlegm you've just loosen. Doesn't make sense. Rather I always suggest mucinex for productive and dextro for nonproductive. Never the combo.

No they don't coughing and sneezing use the same muscles and you don't stop sneezing. It diminishes but does not arrest the ability to cough. The idea (whether it does or not is another question) is the expectorant loosens the gunk and the DM allows you to control the removal at a time, place and rate that does not disrupt your activities of daily life.

 

[confettiflyer]

I recommend and use the guaif-DM combo, Old Timer is right...it's about control and not suppression. When you're hocking up lung junk, it's nice to not have it happen in the middle of a sentence when you're talking to someone.

You'll feel it build up in your lungs and the DM portion will buy you enough time to go outside and cough it out.

but yeah on paper it doesn't make sense but in practice it does.

 

[npage148]

I only recommend guaifanesen for infertility