Quick L-thyroxine Q

[JerryPharmD]

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What is the highest daily dose you have ever seen prescribed for levothyroxine sodium (Synthroid, Levothroid) for a patient?

Thanks.

 

[sdn1977]

200 mcg.

That doesn't seem all that high right??? But, my "patient" was a 25 lb dog.

Since I don't know anything about how levothyroxine is handled in dogs, I called the vet to be sure we were both on the same page.

We were - the vet had been providing vet supplied levothyroxine in escalating doses. We switched the dog over to brand name Synthroid @ 200mcg/day. Over time (months) the dose reduced & stabilized at about 75 mcg - still high at first glance.

I've seen an IV dose of 350mcg, but only as a first bolus in myxedema coma. Doses above 200mcg orally generally have other issues going on - malaborption or drug interactions.

 

[greatdeals225]

300mcg qd

 

[JerryPharmD]

I've personally never seen higher than 300mcg

I ask this because a family member claimed that they took 1000 mcg daily for 3 months 😱 ...10 of the 100 mcg tablets daily..I asked them 4 times and this is what they confirmed

Their body weight cannot be more than 165 pounds...They had radioactive Iodine used to destroy their thyroid, but it seems that their body is destroying L-thyroxine according to what they say...I am very skeptical

 

[bananaface]

300mcg