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If everyone at every center rapidly changed to short course everything, it would be an absolute financial and workforce nightmare.
If everyone at every center rapidly changed to short course everything, it would be an absolute financial and workforce nightmare.
you mean the australian trial, which also showed a trend toward a 3% difference in LR (neither powered to detect this size difference)? There have been no short course vs long course definitive comparisons. This trend of which I speak is in the context of a lower dose of RT in the long course arm than anyone gives inthe real-world when NOM is the intent. I'm not sure how it's reasonable to extrapolate from trials investigating neoadjuvant treatment and single arm trials that focus on those who got a cCR in the first place (the sometimes it works arm) to make decisions about the most efficacious approach to treating gross disease definitively from the outset. I trained at a place that use short-course pre-op and long course definitively, so I'm cool with both.“Trending” isn’t good stats. It’s a 2.7% difference and it’s not SS. I don’t think anyone but those holding on to long course is looking at that number. Respectfully…
If we see something non-significant supporting what we already believe, then we evaluate it in a way that supports what we believe. If something goes against what we believe, we muster all of our critical / analytical skills to say why that data is wrong.
Facts -
Two short course vs LCRT trials show no efficacy difference
Acute toxicity is lower with short course
One study shows worse outcomes with distal disease (other study did not show this, nor did RAPIDO)
RAPIDO has excellent outcomes with the intervention arm and is equivalent or better in almost all outcomes
If you’ve never done one or the other before and are starting anew as a RadOnc, I think most people would probably do SCRT. But, I may be wrong.
Say if SCRT was better and we knew with 100% certainty. It still sucks taking 20-23 fractions off. If we get paid substantially different for the treatment, of course our analysis is going to be somewhat flawed. Our getting a massive haircut to do new things is going to throw a wrench into things. I hate that we have to even think that way.
In this case, I think at the very least, we can say it’s 50/50, but practice pattern don’t support that. I think 90+ % people do LCRT.
If everyone at every center rapidly changed to short course everything, it would be an absolute nightmare. So, people have to hold the line.
Got it! Makes sense.you mean the australian trial, which also showed a trend toward a 3% difference in LR (neither powered to detect this size difference)? There have been no short course vs long course definitive comparisons. This trend of which I speak is in the context of a lower dose of RT in the long course arm than anyone gives inthe real-world when NOM is the intent. I'm not sure how it's reasonable to extrapolate from trials investigating neoadjuvant treatment and single arm trials that focus on those who got a cCR in the first place (the sometimes it works arm) to make decisions about the most efficacious approach to treating gross disease definitively from the outset. I trained at a place that use short-course pre-op and long course definitively, so I'm cool with both.
I've had a few make it out a few years with chemo rads, never to 5 though. Not sure how long they would have made it with just chemo alone....I see the reactions, but I have not cured a pancreatic cancer patient yet in my career without surgery using SBRT or chemorads or whatever.
One of the ways that radonc is trained better. Presenting cost/benefit in somewhat quantitative terms and encouraging mutual decision making. This is particularly important with the type of patients that you see in the community (which are not always very representative of US clinical trial patients). Radiation oncologists routinely do this. For some reason, medical oncologists do not.However, they don’t speak to the patient like that. There is no “choosing wisely” to hold off on the T
Existential threats all around. The last consideration that any of the initiatives in oncology have had is the health of the community radiation oncology work force. Again, I'm OK with academic radonc taking the talent from the last 15 years and finding a way to shrink the field and the time commitment of clinical radonc care over the next 25 years to the point where it fits into the pocket of medical oncology.What's tougher on a patient? Having to travel 1 hour (or more) each way for 5 treatments or 10 minutes each way for 16 treatments?
That was always my thing with this trial. RAPIDO was a trial of early chemo vs +/- post-op chemo (>50% didn't get multiagent chemo). I'm not sure why broad conclusions on the radiation schema were inferred.RAPIDO was an unbalanced trial with much less systemic therapy given in the SOC arm, yet LC still "favored" long course. I'll see what I want to see 😉
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RAPIDO was an unbalanced trial with much less systemic therapy given in the SOC arm, yet LC still "favored" long course. I'll see what I want to see 😉
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Or these guysBased on where that breast surgeon works- is she talking about TOPA?
At this point, new grads should look to academic places to hire them fresh out of training IMHOit’s not the job of large private practices to create jobs for an army of radoncs who shouldn’t have been created in the first place
I start it on first day of treatment 300 x 3 by the third day, and then if no side effects 600 x 3 by week 2In my experience, gabapentin takes so long to actually work (because you need to increase the dose slowly) that by the time it works, therapy is already over. 🤔
She's probably talking about TOPA in Austin. Looks like she's at Austin Cancer Centers. For what it is worth, I had a friend fly down there to interview years ago and was told that they paid straight salary, with no bonus structure. I can't remember the exact number, but I don't recall it being a lot (maybe 280K?). I remember them saying that they had plenty of people knocking on their doors since it was Austin, but judging from their website, they look like they have not hired a new-ish grad in years.Based on where that breast surgeon works- is she talking about TOPA?
I start it on first day of treatment 300 x 3 by the third day, and then if no side effects 600 x 3 by week 2
I generally increase it only after 2-3 weeks, but still I find that even if you reach the desired dose it still takes some time for the actual effect of the treatment to kick in.I start it on first day of treatment 300 x 3 by the third day, and then if no side effects 600 x 3 by week 2
what is your taper up schedule? I find it challenging when it is too complicated. do you just go from 300 x 3 up to 600 x3?
Penn has some papers on this. 300 x 1 first day, 300 x 2 second , 300 x 3 third. If not having any issues after a week, taper up to 600 x 3 over days. Almost all issues I see with neurontin are when starting medication- sleepiness dizziness. If only issue is sleepiness, then 300s during day and 600 at night. In UPenn experience, they were giving 1800-3000/dayI generally increase it only after 2-3 weeks, but still I find that even if you reach the desired dose it still takes some time for the actual effect of the treatment to kick in.
Sounds like the steady state is finding them, not the other way aroundWhat do you disagree with? Finding the steady state is the key, we all agree on that
Imagine being a practicing rad onc, trying to relitigate events from a decade plus ago. Embarrassing!
What do you disagree with? Finding the steady state is the key, we all agree on that
He's the Brick Tamland "I love lamp" of Radiation Oncology.KO is just such a "which way is the wind blowing today" type of "leader". He has a long history of this documented on this thread going back for years. Today he wants a reasonable/balanced number of quality candidates. FWIW Mayo hasn't decreased resident numbers at any of its three programs.
It makes sense when you consider when he matched....KO is just such a "which way is the wind blowing today" type of "leader". He has a long history of this documented on this thread going back for years. Today he wants a reasonable/balanced number of quality candidates. FWIW Mayo hasn't decreased resident numbers at any of its three programs.
It's amazing that it is only now that they claim they want compassionate physicians and in the recent past, women and minorities, as if we never needed them before. There are a lot of great, smart, hardworking, compassionate doctors and soon-to-be doctors out there, many of which we work with or we see for our own care.The gaslighting on twitter over how it's wonderful that RO is now a less competitive specialty is really something. It's like when a CEO gets fired from a job and in news interviews he's like "It's actually great that they fired me... I now have time to do all the important things in life and hang out with my family."
Imagine being a practicing rad onc, trying to relitigate events from a decade plus ago. Embarrassing!
There is a really fun sock puppet account on Twitter that is trying to make friends and influence people! Give her a follow! Go Buckeyes!
There is a really fun sock puppet account on Twitter that is trying to make friends and influence people! Give her a follow! Go Buckeyes!