So I recently ran into a guy in my medical school who was applying in radiology. Apparently he had done some research on a nuclear medicine test that could detect renal cell carcinoma. I guess it used radioactive antibodies or something. He seemed to think that this would be a big problem for pathology in the future. It seems like a lot of the people on this forum think that too.
But how could it? That nuclear study is worse than a biopsy in nearly every way. It is still an invasive test, since it involves injecting radioactive antibodies into a persons body that are meant to react in their kidneys. I'm sure it's incredibly expensive, compared to a glass slide, and all it gives you is a yes or no to RCC. If the patient is negative after his super scan, he just has to get a biopsy anyway. And in any case, there will necessarily be more misdiagnoses by a system that relies entirely on immunophenotype to diagnose a cancer.
Now, in a patient with pathologically confirmed RCC, this study might be amazing for staging and determining response to treatment, and maybe for lesions that can't be biopsied it would be better than nothing, but in the vast majority of cases I can't imagine that it would replace tissue diagnosis.