Hello guys,
I'm really interested about Integrase(IN) Inhibitors and I was searching for their detailed mechanism of action and binding...
What I found is that Mg++ is an important ion for IN activation and a domain in IN binds with it and Raltegravir binds with Mg and chelates it... Here is the question; Does it bind to IN and then to Mg or just binds to Mg, and if the answer is the second, why doesn't it bind to any Mg ion in the body, why just that Mg required for IN activation?
Thanks
I'm really interested about Integrase(IN) Inhibitors and I was searching for their detailed mechanism of action and binding...
What I found is that Mg++ is an important ion for IN activation and a domain in IN binds with it and Raltegravir binds with Mg and chelates it... Here is the question; Does it bind to IN and then to Mg or just binds to Mg, and if the answer is the second, why doesn't it bind to any Mg ion in the body, why just that Mg required for IN activation?
Thanks