Random diabetes question

[skk3]

---

Members don't see this ad.

Hey, was wondering if you future docs could help me understand a diabetes concept.

In FA endocrine, T1D is listed is strong HLA association (HLA-DR3/4) but also described as weak genetic predisposition and also polygenic.

T2D is listed as no HLA association with strong, polygenic genetic predisposition.

How could it possibly be a strong HLA association and a weak genetic predisposition?? Am I just having a brain-fart? Isn't strong HLA association by definition mean your children have a greater chance of having T1D and therefore it is a strong genetic predisposition?

 

[coralis]

It's the other way around:

T2D - strong genetic association.... your mama had it, high chance you'll have it. High monozygotic twin concordance. HLA is not much of an issue of genetic inheritance it's just an association to a particular disease.

T1D - not genetically inherited, but if you have that HLA DR3/4 you might be at risk for it... you might also be at risk for other stuff.... crohn's, RA etc... but it's not like T2D, just ;cause your mama had it, doesn't mean you'll get it.