Renin levels

[doc0610]

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quick review

Primary AI : all the layers are affected, hence, aldosterone, cortisol and androgens are decreased

Now, Central AI : only cortisol and androgens are low. Since, aldosterone isn't dependent on ACTH.

the question here is, what will the levels of renin, aldosterone be in secondary and tertiary disease?
according to wiki it will be low, i don't get why though?

https://en.wikipedia.org/wiki/Adrenal_insufficiency

any inputs here?

 

[bluv1212]

quick review

Primary AI : all the layers are affected, hence, aldosterone, cortisol and androgens are decreased

Now, Central AI : only cortisol and androgens are low. Since, aldosterone isn't dependent on ACTH.

the question here is, what will the levels of renin, aldosterone be in secondary and tertiary disease?
according to wiki it will be low, i don't get why though?

https://en.wikipedia.org/wiki/Adrenal_insufficiency

any inputs here?

If the person is euvolemic/eunatremic, the renin and Aldo will be low. RAAS activation depends on na delivery to the kidneys which may be compromised in hypovolemia/hyponatremia.