Resveratrol supplement - Anti Aging?

[Momus]

http://en.wikipedia.org/wiki/Resveratrol

I know wiki is not the best place to look for information >_> at least it gives basic information about Resveratrol

Resveratrol, a substance commonly found in redwine, and peanuts, has been showed to prolongs life in animal study

They say it might take 5-10 years if it EVER gets FDA approval

Some side effects noted:
"While the health benefits of resveratrol seem promising, one study has theorized that it may stimulate the growth of human breast cancer cells, possibly because of resveratrol's chemical structure, which is similar to a phytoestrogen"

Some of the study presented conflicting results.. Wonder if this cause gynecomastia? The last thing I need is having a man boobs lol -.-... I am willing to give this a try as I believe in redwine and moderate alcohol consumption benefits 🙂

What do you guys think about the preliminary study?

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[meister]

I think its benefits are probably vastly overstated and that the search for the anti-aging "cure" is just a symptom of our society's unhealthy obsession with staying young at all costs.

 

[type b pharmD]

youd probably be better off drinking some good beer and then getting the benefits of resveratrol by eating grapes or grape juice. at least, this is what i do. 😀

 

[gd152]

As a matter of fact, Resveratrol ate away an apple-sized tumor in my twelve year old dog that was dying from colon cancer.

It is still sad to see (but not surprising) future doctors dismissing natural compounds. Why are doctors so often clueless about natural miracles, and why are natural compounds controversial to begin with? Ahh yes, in order to gain widespread acceptance in America, treatments must buy their way into the FDA. Once again, it all comes down to money.

 

[PharmaTope]

natural substances and supplements are great. pharm industry wants you to think otherwise UNTIL THEY CAN PATENT IT FOR THEMSELVES!!

recently various forms of Vit B6 were classified as a drug by the FDA along with a number of other supplements. Thus they would be able to be sold by pharm industry only.


GSK keeps pushing their ****ty Alli product as the only product shown to provide weight loss while an ECA stack destroys alli and even past prescription drugs for weight loss.

 

[Old Timer]

As a matter of fact, Resveratrol ate away an apple-sized tumor in my twelve year old dog that was dying from colon cancer.

It is still sad to see (but not surprising) future doctors dismissing natural compounds. Why are doctors so often clueless about natural miracles, and why are natural compounds controversial to begin with? Ahh yes, in order to gain widespread acceptance in America, treatments must buy their way into the FDA. Once again, it all comes down to money.

No it all comes down to evidence. And the people who who support these products have precious little of it. I would also point out that hemlock, psilocybin,arsenic and dog poop are natural compounds.

When you take 5000 people and give them resveratol and take 5000 people and give them placebo and control for all other factors and you get some benefit from resveratol, let me know. Until then you have what scientists call anecdotal evidence.

There have been studies that show diets high in a certain compund have beneficial effects. The trouble is when they do the same studies with exogenous supplements, they rarely result in the same effects....

As for money, the supplement industry is as poweful and as money hungry as the drug industry. They own so much of Congress they don't even have to prove their claims to the FDA as they are regulated by the USDA.

 

[gd152]

Resveratrol is well-documented to kill colorectal cancer cells. Why don't you do some research on PubMed and Google before spouting off about lack of evidence?

 

[ForcedEntry]

I'm a fan of natural products and supplements, but there are a few things I would like to know first: What is the active ingredient? What is an effective dose? What is a toxic dose? What are the long term effects? Are all sources equipotent? Who harvests it? Does it have to be processed? Who controls quality?

I think Resveratrol is a lot of hype right now. GSK bought the start up for $750 million so maybe there is something to it. But I have to question one thing...if this natural product is so good for you, then you should be able to get enough of it in a natural setting. The scientists behind the drug have stated the amount resveratrol you would need to extend life, equal drinking 1000 bottles of red wine per day. That hardly sounds natural.

 

[PharmaTope]

I'm a fan of natural products and supplements, but there are a few things I would like to know first: What is the active ingredient? What is an effective dose? What is a toxic dose? What are the long term effects? Are all sources equipotent? Who harvests it? Does it have to be processed? Who controls quality?

I think Resveratrol is a lot of hype right now. GSK bought the start up for $750 million so maybe there is something to it. But I have to question one thing...if this natural product is so good for you, then you should be able to get enough of it in a natural setting. The scientists behind the drug have stated the amount resveratrol you would need to extend life, equal drinking 1000 bottles of red wine per day. That hardly sounds natural.

they been selling it as a supplement for a while.

 

[gd152]

It is unlikely resveratrol will extend life much in humans. Most studies show much healthier rats, however, high-dose resveratrol fed rats actually lived shorter lives. High-dose resveratrol induces apoptosis in malfunctioning cells (good in many cases, bad in others), while low-dose resveratrol signals cell longevity. High-dose resveratrol is what kills cancer cells. The only rats that have lived longer than controls are those who ate a calorie-restricted diet and were supplemented moderately with resveratrol.

Low-dose resveratrol partially mimics a calorie-restricted diet in that 95% of genes activated in calorie restriction are activated with low-dose resveratrol, however as we know, calorie restriction is not a cure for aging. The rats still died from other causes.

As for cancer, resveratrol has mounds of evidence in its favor.

 

[PumpkinSmasher]

Resveratrol is well-documented to kill colorectal cancer cells.

That's nice.🙄

 

[gd152]

That's nice.🙄

For everybody dying of colon cancer that does not receive word of potential treatments, here is one man to blame.

 

[Praziquantel86]

For everybody dying of colon cancer that does not receive word of potential treatments, here is one man to blame.

Between randomized controlled trials and your dog, I'll take your dog any day.

 

[Priapism321]

No it all comes down to evidence. And the people who who support these products have precious little of it. I would also point out that hemlock, psilocybin,arsenic and dog poop are natural compounds.

When you take 5000 people and give them resveratol and take 5000 people and give them placebo and control for all other factors and you get some benefit from resveratol, let me know. Until then you have what scientists call anecdotal evidence.

There have been studies that show diets high in a certain compund have beneficial effects. The trouble is when they do the same studies with exogenous supplements, they rarely result in the same effects....

As for money, the supplement industry is as poweful and as money hungry as the drug industry. They own so much of Congress they don't even have to prove their claims to the FDA as they are regulated by the USDA.

AMEN!!!!!!!!!!!!! Show us the ****ing data (in humans, that is, in a scientifically sound manner).

 

[Priapism321]

As for cancer, resveratrol has mounds of evidence in its favor.

Please link the abstracts to the "evidence". Only human data counts. Thanks.

 

[Priapism321]

Resveratrol is well-documented to kill colorectal cancer cells. Why don't you do some research on PubMed and Google before spouting off about lack of evidence?

High concentrations of a lot of things may kill "cells" in a tube. Show me some data regarding the application of the compound in HUMANS with CANCER.

 

[gd152]

I understand your concerns, people. But you seem to be missing the point.

Human trials, such as those required for a drug to gain FDA approval, must proceed through a legal method. Now, I ask any one of you to perform an experiment. Call up any hospital in the country, and tell them that you would like to perform a large-scale clinical trial performed on humans. Their response will be to the effect that they do not undergo clinical trials not sponsored by a pharmaceutical or biotechnological company. Thus, the system is rigged. Natural drugs, under this present system, can never gain broad acceptance because large clinical trials are often difficult or impossible to initiate.

This, however, does not mean that resveratrol or other natural drugs hold no promise. On the contrary, resveratrol has killed multiple cancer cell lines very effectively in vitro and in vivo in multiple animals. But under today's system, the only time a natural drug will gain official medical acceptance is when a pharmaceutical company patents their own version of it for profit.

 

[gd152]

High concentrations of a lot of things may kill "cells" in a tube. Show me some data regarding the application of the compound in HUMANS with CANCER.

I am sorry. But you seem to have not read the thread. Resveratrol kills cancer in vivo.

 

[Priapism321]

I am sorry. But you seem to have not read the thread. Resveratrol kills cancer in vivo.

No, I am reading your asinine assertions quite accurately, and pointing out the glaring problems with the logic you present. I asked for the data which is somewhat of a rhetorical request.

 

[gd152]

No, I am reading your asinine assertions quite accurately, and pointing out the glaring problems with the logic you present. I asked for the data which is somewhat of a rhetorical request.

Please indulge me by pointing out the "glaring problems". At this point, it seems that you are just trying to defend yourself.

 

[Priapism321]

Please indulge me by pointing out the "glaring problems". At this point, it seems that you are just trying to defend yourself.

The biggest being the lack of "CLINICALLY RELEVANT" data. Show me something that matters for patients that are being treated for cancer.

 

[Priapism321]

I understand your concerns, people. But you seem to be missing the point.

Human trials, such as those required for a drug to gain FDA approval, must proceed through a legal method. Now, I ask any one of you to perform an experiment. Call up any hospital in the country, and tell them that you would like to perform a large-scale clinical trial performed on humans. Their response will be to the effect that they do not undergo clinical trials not sponsored by a pharmaceutical or biotechnological company. Thus, the system is rigged. Natural drugs, under this present system, can never gain broad acceptance because large clinical trials are often difficult or impossible to initiate.

The NIH funds projects for natural compounds like this all the time (just read about "antineoplastons" and Dr. Burzynski"). Here is the problem: when any scientific rigor is applied, these compounds FAIL most of the time. Sorry.

 

[gd152]

The biggest being the lack of "CLINICALLY RELEVANT" data. Show me something that matters for patients that are being treated for cancer.

First of all, my friend, I never claimed that resveratrol has cured human cancer in vivo. No, I only said that it has dozens of studies that document apoptosis in human and animal cancer cells in vitro and animal cancer cells in vivo. I also said that it killed cancer cells in my dog.

A clinical study conducted at UC Irvine did show significant reduction in colon cancer in those with diets containing higher amounts of resveratrol. I understand this is not what you are looking for, but it is obvious that you are attacking a straw man - a claim I never made.

 

[gd152]

The NIH funds projects for natural compounds like this all the time (just read about "antineoplastons" and Dr. Burzynski"). Here is the problem: when any scientific rigor is applied, these compounds FAIL most of the time. Sorry.

Of course they do. Were you expecting to disappoint me? I research studies on NIH.gov 1-2 hours a day.

 

[Priapism321]

First of all, my friend, I never claimed that resveratrol has cured human cancer in vivo. No, I only said that it has dozens of studies that document apoptosis in human and animal cancer cells in vitro and animal cancer cells in vivo. I also said that it killed cancer cells in my dog.

A clinical study conducted at UC Irvine did show significant reduction in colon cancer in those with diets containing higher amounts of resveratrol. I understand this is not what you are looking for, but it is obvious that you are attacking a straw man - a claim I never made.

Fair enough. As long as we agree my "straw man" is actually what matters when it comes to taking care of patients.

 

[gd152]

Fair enough. As long as we agree my "straw man" is actually what matters when it comes to taking care of patients.

OK, well there was one poster here who was quite apathetic at the fact that it kills cancer. This upsets me. Now, I am not recommending pharmacists prescribe resveratrol to patients with colon cancer. You would get locked up in jail. What I have done here is initially offered evidence that "this stuff works" and followed up with a disappointment that more people (especially those with nothing to lose) do not know about things that could save them.

 

[Priapism321]

OK, well there was one poster here who was quite apathetic at the fact that it kills cancer. This upsets me. Now, I am not recommending pharmacists prescribe resveratrol to patients with colon cancer. You would get locked up in jail. What I have done here is initially offered evidence that "this stuff works" and followed up with a disappointment that more people (especially those with nothing to lose) do not know about things that could save them.

With only a cursory pubmed query, I would concur that there is a "boat load" of data supporting what you have stated regarding the compound's antineoplastic potential. The amount of basic (bench) research done on the compound actually does excite me to an extent on a scientific level.

 

[PumpkinSmasher]

Between randomized controlled trials and your dog, I'll take your dog any day.

Haha, exactly. I was just trying to point out all the studies he is eluding to do nothing to help me make an evidence based recommendation to a patient and I am glad his dog is okay but that does not convince me of anything.

1-2 hours every day of NIH surfing, I would have thought he could have posted links to "boat loads" of studies in the blink of eye for us to take a look at. I am happy to look on my own but since he already aware of the best studies on the compound, I thought he would share some links...

 

[Old Timer]

A clinical study conducted at UC Irvine did show significant reduction in colon cancer in those with diets containing higher amounts of resveratrol. I understand this is not what you are looking for, but it is obvious that you are attacking a straw man - a claim I never made.

As I pointed out earlier, this has never been duplicated with exogenous supplementation. This is always the case with Vitamin E, Vitamin C, fish oil, etc. Because the data presented is uncontrolled, it fails to meet basic scientific criteria for it to used in humans.

 

[PharMed2016]

I don't know how many of you are familar with Medical Letter (considered unbias) which has been published bi-monthly for awhile now. They recently had an article evaluating Reservatol. In the article, they concluded that Reservatol does seem to mimic calorie-restriction diets in mice but whether or not these results can be extrapolated to humans remains undetermined. So, as someone pointed out... until there is clear randomized clinical trial (RCT) showing a clear relationship to prolonging life... these claims remain at best claims.

Also, interesting enough... the dosing to obtain such effects in mice vary from 4.9-204mg/kg/d. The amount of Reservatol contained within a liter of red wine was found to range from 0.06-36.13. Do the math and figure out how many liters of wine you would need to drink to get it naturally. Therefore for myself (65kg male) - I would need on the lower end 318.5mg to even hit the min amount (which may or maynot hit the MEC) per day. This equates to 8.8L of red wine my good friends in order to meet the min dosing of mice.

http://www.medletter.com/ is the site if you have access to it and want to view the article. It's the 9-21-2009 issue.

 

[npage148]

All you loons touting Resveratrol, check out the aqueous solubility of the compound and then ponder how you are suppose to get it in your body.

100 µM is the limit of resveratrol solubility in an aqueous solution. Take the pill, it won't dissolve in your gut.

You can't get any effect when it can't get in your body and unless you are dissolving it in some harsh solvent, it is not getting into solution.

Think if that before you take it to cure your cancer and make you live forever👎

Also: High dose ethanol kills colon cancer cells too, so I'm gonna tell all my colon Ca patients to get crunked and party!

 

[gd152]

All you loons touting Resveratrol, check out the aqueous solubility of the compound and then ponder how you are suppose to get it in your body.

100 µM is the limit of resveratrol solubility in an aqueous solution. Take the pill, it won't dissolve in your gut.

You can't get any effect when it can't get in your body and unless you are dissolving it in some harsh solvent, it is not getting into solution.

Think if that before you take it to cure your cancer and make you live forever👎

Also: High dose ethanol kills colon cancer cells too, so I'm gonna tell all my colon Ca patients to get crunked and party!

Sorry, the intelligence level displayed on this forum tells me it is clearly not worth my time posting studies. I've wasted enough of my time diffusing arguments that never existed.

 

[npage148]

Sorry, the intelligence level displayed on this forum tells me it is clearly not worth my time posting studies. I've wasted enough of my time diffusing arguments that never existed.

Please post studies showing it has adequate bioavailability to be a viable treatment. I'm a little cranky from a cold, but I'll recognize good data when I see it.

 

[PumpkinSmasher]

Please post studies showing it has adequate bioavailability to be a viable treatment. I'm a little cranky from a cold, but I'll recognize good data when I see it.

There is no arguing with these people. Their enemy is outcome data, if you mention it to them, they become belligerent.

 

[PharMed2016]

There is no arguing with these people. Their enemy is outcome data, if you mention it to them, they become belligerent.

Damn, I was hoping for a more lively debate concerning this topic. Three more weeks till finals are over and a NINE day break. Kudos.

 

[Quiksilver]

All you loons touting Resveratrol, check out the aqueous solubility of the compound and then ponder how you are suppose to get it in your body.

100 µM is the limit of resveratrol solubility in an aqueous solution. Take the pill, it won't dissolve in your gut.

You can't get any effect when it can't get in your body and unless you are dissolving it in some harsh solvent, it is not getting into solution.

Think if that before you take it to cure your cancer and make you live forever👎

Also: High dose ethanol kills colon cancer cells too, so I'm gonna tell all my colon Ca patients to get crunked and party!

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