I'm the editor of Cell AND Nature.
But to respond to the OP, I, too, am beginning to question myself. I had a horrendous undergraduate GPA, and my first MCAT, while a good composite score (34R), included an 8 in PS. Fast-forward to last year, went to BU for their MAMS program, got a 4.0 & top of class, and retook the MCAT for a 38R (14 PS, 12 VR, 12 BS). Started getting more active with volunteering, am getting into academia (teaching a college class next semester), etc. I really thought that would be enough, and have been hopeful that my application will show that I'm not the same person who screwed around during UG and got those piss-poor grades.
I was worried about not including many safeties, but was encouraged by an advisor at BU not to worry about it, that I'd be flush with acceptances, etc. Now I'm not so sure anymore. Now I'm getting pretty scared actually, especially since Georgetown has already passed on me (and I figured if anyone knows how to weigh SMP grades, it'd be them).
I'm 3 Rejections, 0 Interviews, 0 Hold. This is looking pretty grim. Granted, the other two rejections are Mayo and Duke, so it's not exactly an huge surprise, but still. I hear ya. Also, any words of encouragement would be much appreciated.