Sepsis at your hospital

[Nano1971]

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Interestingly enough watched a recent debate about.. Novel Sepsis treatment using a combo meds (Vit C,Thiamine,Steriod)..by one of the Dr who had been practicing for more than 20 years..still some skeptism among medical professions!!!!.. lets wait and see how this breakthrough will unfold..all..are welcomed for thier input......

 

[BidingMyTime]

Say what? I have never heard such a thing, do you have a link? My gut reaction, this sounds like something Dr Oz came up with....

 

[Nano1971]

I will provide a link..

 

[npage148]

Using Vitamin c sounds like Pauling still grasping at vapors trying to repair his reputation

 

[PolarPop]

Say what? I have never heard such a thing, do you have a link? My gut reaction, this sounds like something Dr Oz came up with....

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. - PubMed - NCBI

It's a non-randomized pre and post intervention study of 94 cases. Not really worthy of changing clinical practice on its own but probably not dangerous either.

 

[smercer]

I recall reading an article a couple of years ago about IV Ascorbic Acid (Vit C) treatment in sepsis. I don't recall all of the details, but basically the article stated they gave IV vit C to randomly selected sepsis patients in addition to normal practice procedures vs just normal practice procedures with improved survival rates for the IV Vit C patients. I think it has some potential, but really needs larger studies to make sure the benefits are real. The topic came up after a doctor at one of my institutions ordered it for a severely ill septic patient, however, I do not recall seeing it used again since.

 

[npage148]

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. - PubMed - NCBI

It's a non-randomized pre and post intervention study of 94 cases. Not really worthy of changing clinical practice on its own but probably not dangerous either.

There are some scathing commentary about this study in the same journal. They are quite entertaining

 

[CetiAlphaFive]

I don't see any possible downside to pumping someone full of vitamin C if they're going to die anyway.

 

[Saiyo]

Eh, it's one of those things they can do it if they want. Banana bags also don't need to be ordered for everyone in the ER but it's still done.

 

[Rockinacoustic]

Have anecdotally seen it used- can't comment on outcomes but when you're failing on 4 pressors why not.

I'd rather our intensivists mess around this combo than Angiotensin II for more $ and poorer outcomes.

 

[TimeZero]

The regimen is referred to as Marik's cocktail. Here is a link for anyone looking for a summary.

PulmCrit- Metabolic sepsis resuscitation: the evidence behind Vitamin C