- Joined
- Dec 1, 2010
- Messages
- 215
- Reaction score
- 3
What does Mirtazapine's antagonism of 5HT1, 5HT2, 5HT3 do? How do they contribute to its effects as an antidepressant / sedative / appetite enchancer?
.
.
Last edited:
It seems like overkill, but if your up at 3am because you are worried about useless, minute details then just read the "correspondence to clinical effects" section here:
http://en.wikipedia.org/wiki/Mirtazapine
What does Mirtazapine's antagonism of 5HT1, 5HT2, 5HT3 do? How do they contribute to its effects as an antidepressant / sedative / appetite enchancer?
The TL;DR of that wikipedia link is that Mirtazapine is:
- an indirect agonist of central 5-HT1A receptors, which increases levels of 5-HT in the brain (antidepressive).
- an inhibitor of 5-HT2C in the VTA; 5-HT2C is responsible for inhibiting release of DA and NE in the reward zone. Inhibition of the 5-HT2C receptor disinhibits DA/NE release, resulting in antidepressant/appetite effects.
- a 5HT3 blocker, involved in antiemetic activity.
- a strong H1 inverse agonist a.k.a. an antihistamine (much like how diphenhydramine causes sedation) minus the anticholinergic effects seen with diphenhydramine. I think it binds to the inactive state of the histamine receptor, thereby blocking the release of histamine and causing sedation.