SGLT2 inhibitors

[Northerncardinal]

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What's the mechanism of hyperkalemia by -flozins?

 

[Anti-PD1]

SGLT2 is a Na+/Glucose co-transporter, like SGLT1 in the gut (oral fluid tx for Cholera). If you block it, less Na+ is reabsorbed on the basolateral Na/K pump. And so, less K is transported from the interstitium into the tubular cell to be excreted. Hence, hyperkalemia. Careful with other hyperkalemic drugs (ACE/ARBs).

Diabetes is itself an independent risk factor for hyperkalemia.

 

[Northerncardinal]

SGLT2 is a Na+/Glucose co-transporter, like SGLT1 in the gut (oral fluid tx for Cholera). If you block it, less Na+ is reabsorbed on the basolateral Na/K pump. And so, less K is transported from the interstitium into the tubular cell to be excreted. Hence, hyperkalemia. Careful with other hyperkalemic drugs (ACE/ARBs).

Diabetes is itself an independent risk factor for hyperkalemia.

Thanku so much for this awesome explanation!