SHBG

[aspiringmd1015]

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What all associations are we supposed to know regarding SHBG? as in FA has a small section on it on pg 321 in endo, but im not sure what all we're suppose to know about it. I'm assuming more than just whats written there.

 

[seminoma]

Probably just need to know its role in the presentation of PCOS and liver failure.

 

[aspiringmd1015]

okay thanks, and an offshoot of that question, what about serotnonin receptors? theres many different kinds as everyone knows, but what is step 1 relevant. ie 5-htb, a 5-ht2 etc.

 

[seminoma]

Don't know any of them. Never came up on UW or my exam.

 

[aspiringmd1015]

i remembering seeing a quesiton about in UW regarding Buspirone i believe. But myabe it didnt ask what receptor it was working on, guess not then. THanks.

 

[MudPhud20XX]

What all associations are we supposed to know regarding SHBG? as in FA has a small section on it on pg 321 in endo, but im not sure what all we're suppose to know about it. I'm assuming more than just whats written there.

I just heard this from DIT. So in PCOS, increased insulin decreases the expression go SHBG, thus contributing to increased adrogen that leads to the symptoms of hyperandrogensim.

 

[you.old]

okay thanks, and an offshoot of that question, what about serotnonin receptors? theres many different kinds as everyone knows, but what is step 1 relevant. ie 5-htb, a 5-ht2 etc.

Just know the sites of Buspirone, Ondansetron, Triptans. Better if you know 2nd messenger system as well.

What all associations are we supposed to know regarding SHBG? as in FA has a small section on it on pg 321 in endo, but im not sure what all we're suppose to know about it. I'm assuming more than just whats written there.

Know the fact that SHBG and Thyroid BG increase during pregrancy or with OCP or with increased estrogen state.