Should I bring up [insert very personal issue here] in my application?

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An important personal issue to you = extra crap to deal with for the board reviewer.
 
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Depends on what the issue is and what role it plays in you wanting to go into your specialty:

Ex: Witnessed parent die a long, painful death from cancer and now want to go into palliative care? It plays a role and I could see it as part of a personal statement

Ex: I was a heroin addict til last year and now want to go into addiction medicine?
Don't mention it...at all.
 
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