5 hours by flight? Don’t underestimate the amount of time check in, security, getting to and from the airport takes.
5 hours by car? You probably won’t reach your hotel until 8-10PM. If you have the stamina to do an interview, drive 5 hours, get right to sleep to wake up and do another interview, then more power to you.
Keep in mind that a bad or lazy interview will destroy your chances. Proceed at your own risk.