"sink condition" and dissolution rate

Discussion in 'Pharmacy' started by gablet, Sep 17, 2005.

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  1. gablet

    gablet Senior Member 5+ Year Member

    Mar 20, 2005
    This may seem like a simple question, but it is just not clicking for me. Can someone please explain what the "sink condition" is? What would be a situation where a drug would be immediately absorbed upon dissolution - does it only happen in testing?

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  3. gablet

    gablet Senior Member 5+ Year Member

    Mar 20, 2005
    Well, I found it (not that anyone cares :( )

    "Sink condition assures the complete dissolution of the drug. Sink conditions re fer to the excess solubilizing ca p a c i ty of the dissolution medium."
  4. pharmaz88

    pharmaz88 10+ Year Member

    Nov 8, 2003
    gotta' love 'ceutics. :)
  5. jboogie

    jboogie SDN Donor 5+ Year Member

    Sep 25, 2004

    My understanding, Gabby is that this is right. It is when the Saturation point is so much lower than the drug entering solution that it is negligible and therefore, you do not need to account for it in the equation. ...Sorry this is too late for the test.... Hope you did well.
  6. ngphm7


    Oct 10, 2009
    Sink condition: insignificance accummulation of drug in receptor (i.e. that drug cant reach the receptor chamber, maybe because of removal by blood flow)

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