Small intestine resection

[Azmedstudent]

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How would a small intestine resection affect the bioavailibilty of orally administered drugs. Would it decrease the bioavailibility or would it remain unchanged?

Thanks

 

[docB]

Possibly. Depends on which part of the intestine was removed and which drug you're talking about.

You should really try the Internal Med forum and post it as a GI question. We're just dumb ER docs here.

 

[Seaglass]

Or you could do your own homework.

 

[Azmedstudent]

Or you could do your own homework.

Wow seaglass, you are SO helpful. I have already been reading various pharm texts, and searching the internet for various articles. I've been looking for the answer, I just thought that I could use people who have much more experience than myself as another source of information, but sorry for bothering you by me trying to learn and understand a concept. You will make a great mentor someday. 👎

DocB thank you for replying, I will post my question in the IM forum.

 

[droliver]

How would a small intestine resection affect the bioavailibilty of orally administered drugs. Would it decrease the bioavailibility or would it remain unchanged?

This will depend on what's resected & the extent of residual SB present. The gastric bypasses or other GI reconstructive procedures using lengths of bypassed intestine (mostly whipples, some ulcer operations, and a rare trauma case or two) can cause PROFOUND problems with malabsorption which make many oral medications very unpredictable in their bioavailability. This is in addition to some issues with protein, vitamin (most B vitamins), and fatty absorption. Most SB resections in isolation cause few problems, even of fairly signifigant lengths. In addition the resection of the ileo-cecal valve can rapidly speed up transit & affect substances that require longer time in the terminal illeum for absorption

 

[lattimer13]

Or you could do your own homework.

👎 🙄

 

[Seaglass]

Wow seaglass, you are SO helpful. I have already been reading various pharm texts, and searching the internet for various articles. I've been looking for the answer, I just thought that I could use people who have much more experience than myself as another source of information, but sorry for bothering you by me trying to learn and understand a concept. You will make a great mentor someday.

Bah. Humbug.

 

[funkless]

BOOOOO