spironolactone dec. mortality in class III and IV CHF pxts. in uworld "spironolactone in HF patients are more than likely secondary to inhibition of the neurohormonal effects of aldosterone leading to decreased ventricular remodeling and cardiac fibrosis". Can anyone explain it beyond this? what neurohormonal effect? Is it because spironolactone inhibits aldosterone working on the heart compared to other diuretics which decreases aldosterone altogether?