SSRIs and Downregulation

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DrMasochist

Full Member
10+ Year Member
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When they say it takes 4-8 weeks for SSRIs to work therapeutically, is this due to the down-regulation of the receptors? Wouldn't down-regulating something have a decreased overall effect?

I would think the period before the 4-8 weeks, the patient would be feeling jittery and anxious and super happy.