Side effects are just as common - dry mouth, nausea, consptiaption, fatigue, dizziness and headache with photosensitivity reactions due to red pigment says the Maudsley Guidelines.
One study found it to be comparable to Imipramine 150mg (standard dosing to form a comparison across species of drug) and as effective in mild-moderate depression.
None of the older trials lasted longer than 8 weeks. This one only lasted 6 weeks. So far, plenty of research says it's as effective the global 150mg imipramine (or paroxetine 20mg, e.g., and so on) in mild-moderate, this one says effective in moderate-severe. HOWEVER, we need long term studies not simply 6 weeks which sort of makes it pointless.
Major concern with HP IMHO is non-standard preparations without government control of the standards and more importantly depression should be diagnosed by trained professionals - the problem is people diagnosing themselves when the cause could be purely physical (e.g., on propranolol, hypothyroidism) or psychological (e.g., psychosocial stressors).
Evidence for SJW is inconsistent and all trials have been under 8 weeks. The notable word in the full article (in PDF on the site) is that it is effective in acute treatment. Also, the run-in was single-blinded.
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