Hi- I took Step 1 last year-here's my advice: -It was very heavy in Pathology and Physiology. -1st year stuff (gross, embryology, histo) was barely covered; high-yield books were plenty for those. -Don't forget about behavioral science and statistics- there was a decent amount of that on mine. It can make the difference between a good and a great score. -Pharmacology questions vary, though they seem to like cardio drugs. -Biochemistry was clinically oriented- mostly diseases of metabolism; there were no hard-core mechanisms on my test. -They love clinical vignettes so practice tons of those. Q bank and the USMLE CD were helpful. -At our school, we take NMBE's at the end of each 3rd year rotation and they seem to be leaning more and more toward problem-solving and clinical cases, so the more you practice, the better. -Try to read "First AID for the Boards" in the last week before the boards. It is an amazing, easy-to-read book that I feel really hit Step 1 head on. Good luck!