PrussianBlue1

10+ Year Member
Apr 14, 2008
47
0
Status
Medical Student
How does ephedrine causes hyPOtension when it stimulates catecholamine release??? :confused::confused::confused:
 

agranulocytosis

10+ Year Member
Sep 23, 2007
559
32
Status
Fellow [Any Field]
I think it causes vasoconstriction and thus hypertension. Although, I do know that it was used as a nasal decongestant, and in Pharm I I had trouble realizing that vasoconstriction of the vessels in the nasal mucosa leads to less edema and a relief of nasal congestion. Maybe this is your misundestanding?
 
OP
P

PrussianBlue1

10+ Year Member
Apr 14, 2008
47
0
Status
Medical Student
thanks. i was reading it wrong...just like you said it causes hypertension. I also noticed that the same analogy can be used for epinephrine in the treatment of glaucoma, this how it reduces aqueous humor production. Although it is only of limited use since we don't use it in closed-angle glaucoma. :)
 

agranulocytosis

10+ Year Member
Sep 23, 2007
559
32
Status
Fellow [Any Field]
Yea I figured it was read wrong. Happens to me all the time, like when a drug is used versus what the drug's effects are.
 

ReidSternberg

10+ Year Member
Apr 7, 2008
19
0
Status
thanks. i was reading it wrong...just like you said it causes hypertension. I also noticed that the same analogy can be used for epinephrine in the treatment of glaucoma, this how it reduces aqueous humor production. Although it is only of limited use since we don't use it in closed-angle glaucoma. :)
How again does epi treat glaucoma? How does it reduce humor production? I just dont.. I just don't know about the epi mechanism. Those little epi's they run circles around me. :idea:
 
OP
P

PrussianBlue1

10+ Year Member
Apr 14, 2008
47
0
Status
Medical Student
it is not a very efficient treatment but i believe it is through vasoconstriction, although the problem is the mydriasis it produces is one thing you don't want in the treatment of glaucoma, since it can increase your ocular pressure.

In the end, I think it was discovered empirically.
 

Lamborghini1315

Sleep deprived
10+ Year Member
7+ Year Member
Jun 7, 2006
918
1
33
Status
MD/PhD Student
How does ephedrine causes hyPOtension when it stimulates catecholamine release??? :confused::confused::confused:
There's something called as rebound effect...go back to your notes you will come across this. Extremely important to understand when dealing with cardiac patients..also keep in mind you may not be stimulating all adrenergic receptors. So you might have hypertension but hypotension in peripheral circulation.