T-cell and B-cell proliferation

[Deepa100]

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When T or B-cells proliferate, are their respective clones same as the parent?

 

[minhaj]

b-cells proliferate when an antigen is encountered by the immune system. the b-cells that are capable of producing antibodies against this specific antigen are produced in greater numbers, along with memory cells (for quicker response in case of another infection).

cytotoxic t-cells proliferate when there is a disease like cancer which results in abnormal self-cells, or when a cell starts producing viral proteins (as a result of a viral infection). proliferation of helper t-cells occurs when the helper t-cells encounter antigens presented by the APC in the lymph nodes.

hope that helps

 

[Deepa100]

b-cells proliferate when an antigen is encountered by the immune system. the b-cells that are capable of producing antibodies against this specific antigen are produced in greater numbers, along with memory cells (for quicker response in case of another infection).

cytotoxic t-cells proliferate when there is a disease like cancer which results in abnormal self-cells, or when a cell starts producing viral proteins (as a result of a viral infection). proliferation of helper t-cells occurs when the helper t-cells encounter antigens presented by the APC in the lymph nodes.

hope that helps

No, not really.
I am asking about the genetic make up of the clones.

 

[minhaj]

lol my bad, it was really late when i posted that. anyways, do a search on clonal selection and you will probably find your answer.

 

[Ibn Rushd]

T cell clones will be identical, but B cell clones will not. Reason being, B cells undergo additional genetic changes after activation / during proliferation: somatic hypermutation and class switch recombination, namely. These mechanisms ensure that one activated B cell is ultimately able to secrete a variety of antibodies with regards to both affinity and effector functions.