Most of things things you can do to save money on taxes require you to spend even more than you'd get back (charity, solar panels/energy efficiency stuff, etc.) All are great things to do, but not for the sole purpose of paying less taxes as you would have less take-home.
Getting married (to someone who doesn't work or doesn't make much) is probably would have the biggest impact on your taxes, if you aren't already married. Otherwise, becoming a sole proprietor/LLC/S-corp is the way to deduct a lot of things--many of which you don't have to pay for if you're an employee. I pay for and deduct my own malpractice insurance, biller fees, professional licensing fees, professional memberships, health insurance, etc. If I worked at a few hospitals I could deduct a lot more of my car/miles, but I mostly work at one hospital which is basically a commute to the IRS, even if I have a home office. Which I used to have and then I decided it wasn't worth it as you can't use it for literally anything other than business. So we turned it into a combined office (non-deductible)/library/LegoLand (Legos have to go somewhere, and it's a great sunny room for them!).
If you are a 1099 contractor, then make sure you're taking advantage of the pass through deduction. And talk to your accountant about having your business prepay your state taxes to workaround the SALT deduction cap, as most states now allows this and the IRS has blessed the workaround. I don't do it myself since CA doesn't let sole proprietors do it, and realistically it wouldn't save enough to make it worth the far greater hassle/complexity of being an s corp.
