It totally depends on your state, marital status, how many kids you have, retirement plan, business expenses, other deductions, etc.
Aside from getting married and living in a state like WA or TX that doesn’t tax income, the biggest deductions you have are your business deductions, pass-through deduction, and retirement (you can put up to $61k into a solo 401k per year). I opted for a more expensive health care plan since I can deduct it anyway, and it lets my wife and I feel more comfortable knowing we’ve pre-paid our healthcare expenses, so there is less of a chance for surprises. We’d save a bit of money with a high-deductible plan, but when I did the math based on prior years’s expenses, it wasn’t worth it.
Take a look at WhiteCoatInvestor’s blogs for tips on lowering your tax burden. An accountant should be able to give you a lot of advice as well.