Which of the following compounds, when added to stored whole blood, BEST prevent clotting?
A) citrate B) glutamate C) succinate D) gamma-carboxyglutamate
It seems as though more positions in which Ca2+ can bind (chelate Ca2+) would promote clotting as opposed to preventing it. Ca2+ ions are important for blood clotting and the more negatively charged sites, the more Ca2+ can bind and thus the better the compound is for the formation of clotting. So, I would assume that the worst chelator would be the compound that would be the best at preventing clotting and the worst chelator would be glutamate since it has the least amount of negatively charged sites along with that interaction between the alpha-carboxyl group and the NH3+ group. Am I missing something here?
A) citrate B) glutamate C) succinate D) gamma-carboxyglutamate
It seems as though more positions in which Ca2+ can bind (chelate Ca2+) would promote clotting as opposed to preventing it. Ca2+ ions are important for blood clotting and the more negatively charged sites, the more Ca2+ can bind and thus the better the compound is for the formation of clotting. So, I would assume that the worst chelator would be the compound that would be the best at preventing clotting and the worst chelator would be glutamate since it has the least amount of negatively charged sites along with that interaction between the alpha-carboxyl group and the NH3+ group. Am I missing something here?
