TBR: Edema Definition Wrong?

[justadream]

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TBR Bio Book I page 184 #58

“What would be a physiological effect of uremia [having an increased urea plasma concentration]?”


Answer: Edema. “Edema means an accumulation of fluid in the intracellular [within cells] spaces, leading to tissue swelling”


Isn’t this incorrect? From consulting physio textbooks, I found that edema is when fluid accumulates in interstitial space. For example, Silverthorn Physio says “An immobilized limb frequently swells from the accumulation of fluid in the interstitial space, a condition known as edema”



So using Silverthorn’s definition of edema (not TBR’s):



If the urea plasma level is increased (that is, the concentration of urea in the blood is increased), then shouldn’t the blood’s osmotic pressure increase, leading to RETENTION of fluid in the BLOOD?



Thus, fluid would NOT leak into the intercellular space.

 

[DrknoSDN]

Yes, if for some reason you had uremia induced edema is normally from kidney failure. If you had increased urea, and only urea in only the plasma and nowhere else, and also had fully functional kidneys then yes, fluid would be drawn into the circulatory system from osmotic pressure similar to albumin action.

That does not happen in reality.

 

[justadream]

@DrknoSDN

Ok that makes sense. I keep trying to apply concepts but then there's cases like this where they don't apply so simply 🙁