Does anyone know how one molecule can inhibit so many different receptors? The whole lock and key idea doesn't work here, considering that TCAs inhibit H1 receptors, muscarinic receptors, alpha-1 receptors, etc...
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Step I TCAs and receptor affinity?
Started by blueboyscholar
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Google their structures, espcially http://en.wikipedia.org/wiki/File:Iprindole-structure.png
I dunno to me I can see how this could block stuff up, kinda similar.
Look at epinephrine compared to that.
that is kind of what I was leaning twd..TY
Structure = Function.
This is Iprindole a TCA ^
This is Serotonin^
This is Epinephrine -
Serotonin binding site : http://www.jbc.org/content/277/19/17170/F2.large.jpg
Do you see how this could get in and gum up the works? Not magic. You see that they have 4 steps in how serotonin binds eventually that big extra ring is going to keep stuff from working properly.
This is Iprindole a TCA ^
This is Serotonin^
This is Epinephrine -
Serotonin binding site : http://www.jbc.org/content/277/19/17170/F2.large.jpg
Do you see how this could get in and gum up the works? Not magic. You see that they have 4 steps in how serotonin binds eventually that big extra ring is going to keep stuff from working properly.
